Comparative activities of agonists of active duodenal bicarbonate secretion in the guinea pig

H. S. Odes, R. Muallem, R. Reimer, M. Schwenk, W. Beil, K. Fr Sewing

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The comparative activity of agonists of duodenal bicarbonate secretion was studied in the anesthetized guinea pig, where the duodenal lumen was perfused with 24 mmol/1 NaHCO to ensure active secretion of bicarbonate. Agonists were infused alone and in combination. Dibutyryl 3',5'-cyclic adenosine monophosphate, vasoactive intestinal polypeptide (VIP) and prostaglandin E2 (PGE2) were strong stimulants of bicarbonate secretion. Theophylline, dibutyryl 3',5'-cyclic guanosine monophosphate, glucagon and prostaglandin F2a (PGF2a) were weaker agonists, and secretin had no effect. Combinations of any two of VIP, PGE2 and glucagon depressed bicarbonate secretion, whereas combinations of PGE2 and PGF2a, VIP and PGE2, and glucagon and PGF2a increased bicarbonate secretion. The data indicate that cAMP and other secondary messengers may mediate duodenal bicarbonate secretion.

Original languageEnglish
Pages (from-to)410-416
Number of pages7
Issue number6
StatePublished - 1 Jan 1994


  • Dibutyryl 3′,5′-cyclic adenosine
  • Guanosine monophosphate glucagon
  • Monophosphate dibutyryl 3′,5′-cyclic
  • Prostaglandin E<inf>2</inf>
  • Prostaglandin F<inf>2α</inf>
  • Secretin
  • Vasoactive intestinal polypeptide
  • theophylline

ASJC Scopus subject areas

  • Gastroenterology


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