Comparative activities of agonists of active duodenal bicarbonate secretion in the guinea pig

H. S. Odes; R. Muallem; R. Reimer; M. Schwenk; W. Beil; K. Fr Sewing

doi:10.1159/000201174

Comparative activities of agonists of active duodenal bicarbonate secretion in the guinea pig

H. S. Odes, R. Muallem, R. Reimer, M. Schwenk, W. Beil, K. Fr Sewing

Medical School for International Health

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The comparative activity of agonists of duodenal bicarbonate secretion was studied in the anesthetized guinea pig, where the duodenal lumen was perfused with 24 mmol/1 NaHCO to ensure active secretion of bicarbonate. Agonists were infused alone and in combination. Dibutyryl 3',5'-cyclic adenosine monophosphate, vasoactive intestinal polypeptide (VIP) and prostaglandin E₂ (PGE₂) were strong stimulants of bicarbonate secretion. Theophylline, dibutyryl 3',5'-cyclic guanosine monophosphate, glucagon and prostaglandin F_2a (PGF_2a) were weaker agonists, and secretin had no effect. Combinations of any two of VIP, PGE₂ and glucagon depressed bicarbonate secretion, whereas combinations of PGE₂ and PGF_2a, VIP and PGE₂, and glucagon and PGF_2a increased bicarbonate secretion. The data indicate that cAMP and other secondary messengers may mediate duodenal bicarbonate secretion.

Original language	English
Pages (from-to)	410-416
Number of pages	7
Journal	Digestion
Volume	55
Issue number	6
DOIs	https://doi.org/10.1159/000201174
State	Published - 1 Jan 1994

Keywords

Dibutyryl 3′,5′-cyclic adenosine
Guanosine monophosphate glucagon
Monophosphate dibutyryl 3′,5′-cyclic
Prostaglandin E<inf>2</inf>
Prostaglandin F<inf>2α</inf>
Secretin
Vasoactive intestinal polypeptide
theophylline

ASJC Scopus subject areas

Gastroenterology

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10.1159/000201174

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title = "Comparative activities of agonists of active duodenal bicarbonate secretion in the guinea pig",

abstract = "The comparative activity of agonists of duodenal bicarbonate secretion was studied in the anesthetized guinea pig, where the duodenal lumen was perfused with 24 mmol/1 NaHCO to ensure active secretion of bicarbonate. Agonists were infused alone and in combination. Dibutyryl 3',5'-cyclic adenosine monophosphate, vasoactive intestinal polypeptide (VIP) and prostaglandin E2 (PGE2) were strong stimulants of bicarbonate secretion. Theophylline, dibutyryl 3',5'-cyclic guanosine monophosphate, glucagon and prostaglandin F2a (PGF2a) were weaker agonists, and secretin had no effect. Combinations of any two of VIP, PGE2 and glucagon depressed bicarbonate secretion, whereas combinations of PGE2 and PGF2a, VIP and PGE2, and glucagon and PGF2a increased bicarbonate secretion. The data indicate that cAMP and other secondary messengers may mediate duodenal bicarbonate secretion.",

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author = "Odes, {H. S.} and R. Muallem and R. Reimer and M. Schwenk and W. Beil and Sewing, {K. Fr}",

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T1 - Comparative activities of agonists of active duodenal bicarbonate secretion in the guinea pig

AU - Odes, H. S.

AU - Muallem, R.

AU - Reimer, R.

AU - Schwenk, M.

AU - Beil, W.

AU - Sewing, K. Fr

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The comparative activity of agonists of duodenal bicarbonate secretion was studied in the anesthetized guinea pig, where the duodenal lumen was perfused with 24 mmol/1 NaHCO to ensure active secretion of bicarbonate. Agonists were infused alone and in combination. Dibutyryl 3',5'-cyclic adenosine monophosphate, vasoactive intestinal polypeptide (VIP) and prostaglandin E2 (PGE2) were strong stimulants of bicarbonate secretion. Theophylline, dibutyryl 3',5'-cyclic guanosine monophosphate, glucagon and prostaglandin F2a (PGF2a) were weaker agonists, and secretin had no effect. Combinations of any two of VIP, PGE2 and glucagon depressed bicarbonate secretion, whereas combinations of PGE2 and PGF2a, VIP and PGE2, and glucagon and PGF2a increased bicarbonate secretion. The data indicate that cAMP and other secondary messengers may mediate duodenal bicarbonate secretion.

AB - The comparative activity of agonists of duodenal bicarbonate secretion was studied in the anesthetized guinea pig, where the duodenal lumen was perfused with 24 mmol/1 NaHCO to ensure active secretion of bicarbonate. Agonists were infused alone and in combination. Dibutyryl 3',5'-cyclic adenosine monophosphate, vasoactive intestinal polypeptide (VIP) and prostaglandin E2 (PGE2) were strong stimulants of bicarbonate secretion. Theophylline, dibutyryl 3',5'-cyclic guanosine monophosphate, glucagon and prostaglandin F2a (PGF2a) were weaker agonists, and secretin had no effect. Combinations of any two of VIP, PGE2 and glucagon depressed bicarbonate secretion, whereas combinations of PGE2 and PGF2a, VIP and PGE2, and glucagon and PGF2a increased bicarbonate secretion. The data indicate that cAMP and other secondary messengers may mediate duodenal bicarbonate secretion.

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KW - Monophosphate dibutyryl 3′,5′-cyclic

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KW - Prostaglandin F<inf>2α</inf>

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KW - Vasoactive intestinal polypeptide

KW - theophylline

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ER -

Comparative activities of agonists of active duodenal bicarbonate secretion in the guinea pig

Abstract

Keywords

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