@article{b57073d484d0444fba7199f0af66034c,
title = "Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model",
abstract = "This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.",
keywords = "H-FIRE, electroporation, muscle contraction, pulsed field ablation",
author = "Eyal Heller and Tomas Garcia-Sanchez and Yonatan Moshkovits and Raul Rabinovici and Dvora Grynberg and Amit Segev and Asirvatham, {Samuel J.} and Antoni Ivorra and Elad Maor",
note = "Funding Information: Funded by the Nicholas and Elizabeth Shlezak Super Center for Cardiac Research and Biomedical Engineering at Tel Aviv University; Mayo Clinic–Sheba innovation grant; project (PID2019-110120RBI00/AEI/10.13039/501100011033) from the Ministry of Science, Innovation, and Universities; and the State Research Agency of the Spanish government and by the Beatriu de Pinos program from the Ministry of Business and Knowledge of the Government of Catalonia (grant identifier: 2017 BP 00032). Dr Ivorra gratefully acknowledges financial support by the Catalan Institution for Research and Advanced Studies (ICREA) under the ICREA Academia program. Dr Garcia-Sanchez is a consultant for Arg{\'a} Medtech SA. Dr Ivorra is a consultant for Arg{\'a} Medtech SA. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: {\textcopyright} 2021 American College of Cardiology Foundation",
year = "2021",
month = aug,
day = "1",
doi = "10.1016/j.jacep.2021.05.003",
language = "English",
volume = "7",
pages = "959--964",
journal = "JACC: Clinical Electrophysiology",
issn = "2405-5018",
publisher = "Elsevier USA",
number = "8",
}