Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model

Eyal Heller; Tomas Garcia-Sanchez; Yonatan Moshkovits; Raul Rabinovici; Dvora Grynberg; Amit Segev; Samuel J. Asirvatham; Antoni Ivorra; Elad Maor

doi:10.1016/j.jacep.2021.05.003

Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model

Eyal Heller, Tomas Garcia-Sanchez, Yonatan Moshkovits, Raul Rabinovici, Dvora Grynberg, Amit Segev, Samuel J. Asirvatham, Antoni Ivorra, Elad Maor

Department of Electrical & Computer Engineering

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.

Original language	English
Pages (from-to)	959-964
Number of pages	6
Journal	JACC: Clinical Electrophysiology
Volume	7
Issue number	8
DOIs	https://doi.org/10.1016/j.jacep.2021.05.003
State	Published - 1 Aug 2021

Keywords

H-FIRE
electroporation
muscle contraction
pulsed field ablation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

Access to Document

10.1016/j.jacep.2021.05.003

Cite this

@article{258ed0936a8346ae90790411bd2bf718,

title = "Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model",

abstract = "This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.",

keywords = "H-FIRE, electroporation, muscle contraction, pulsed field ablation",

author = "Eyal Heller and Tomas Garcia-Sanchez and Yonatan Moshkovits and Raul Rabinovici and Dvora Grynberg and Amit Segev and Asirvatham, \{Samuel J.\} and Antoni Ivorra and Elad Maor",

note = "Publisher Copyright: {\textcopyright} 2021 American College of Cardiology Foundation",

year = "2021",

month = aug,

day = "1",

doi = "10.1016/j.jacep.2021.05.003",

language = "English",

volume = "7",

pages = "959--964",

journal = "JACC: Clinical Electrophysiology",

issn = "2405-500X",

publisher = "Elsevier USA",

number = "8",

}

TY - JOUR

T1 - Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model

AU - Heller, Eyal

AU - Garcia-Sanchez, Tomas

AU - Moshkovits, Yonatan

AU - Rabinovici, Raul

AU - Grynberg, Dvora

AU - Segev, Amit

AU - Asirvatham, Samuel J.

AU - Ivorra, Antoni

AU - Maor, Elad

PY - 2021/8/1

Y1 - 2021/8/1

N2 - This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.

AB - This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.

KW - H-FIRE

KW - electroporation

KW - muscle contraction

KW - pulsed field ablation

UR - https://www.scopus.com/pages/publications/85112020603

U2 - 10.1016/j.jacep.2021.05.003

DO - 10.1016/j.jacep.2021.05.003

M3 - Article

C2 - 34217666

AN - SCOPUS:85112020603

SN - 2405-500X

VL - 7

SP - 959

EP - 964

JO - JACC: Clinical Electrophysiology

JF - JACC: Clinical Electrophysiology

IS - 8

ER -

Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this