Comparison of embryo quality between intracytoplasmic sperm injection and in vitro fertilization in sibling oocytes

R. Yoeli, R. Orvieto, J. Ashkenazi, M. Shelef, Z. Ben-Rafael, I. Bar-Hava

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Background: The aim of the present study was to compare the quality of embryos derived from sibling oocytes by in vitro fertilization (IVF) or ICSI. Methods: Consecutive patients with a less than 40% fertilization rate in a previous standard IVF cycle or with relative male factor infertility were recruited for the study. The oocytes retrieved from each patient were divided into two groups for either conventional insemination (group A) or ICSI (group B). Power analysis showed that to detect a 25% difference in the rate of high-quality embryos between the groups with a power of 0.8, at least 1,200 oocytes were needed in each group. Results: One hundred seventy-seven patients were included in the study. Group A was comprised of 1,526 oocytes and group B of 1,480 sibling oocytes. As expected, the fertilization rate was significantly higher in group B than group A (67.1 vs. 43.6%, p<0.001). No significant between-group differences were observed in cleavage rate (92.7 and 89.7%, respectively) and the rate of either grade A embryos (22.6 and 23.9%, respectively) or grade A1 embryos (37.3 and 33.5%, respectively). However, in the subgroup of patients with relative male-factor infertility (n=36), the rate of grade A1 embryos was significantly higher in the IVF than the ICSI group (46.4 vs. 29.0%, respectively, p=0.02). Conclusions: Embryo quality does not seem to be influenced by the mode of fertilization (IVF or ICSI). We assume that embryo quality depends on intrinsic factors of the gametes involved rather than on the fertilization process per se.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalJournal of Assisted Reproduction and Genetics
Volume25
Issue number1
DOIs
StatePublished - 1 Jan 2008
Externally publishedYes

Keywords

  • Embryo quality
  • In vitro fertilization
  • Intracytoplasmic sperm injection
  • Sibling oocytes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

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