Comparison of seroprevalences of human herpesvirus-6 and -7 in healthy blood donors from nine countries

Gerhard R.F. Krueger; B. Koch; N. Leyssens; Z. Berneman; J. Rojo; C. Horwitz; T. Sloots; M. Margalith; J. D. Conradie; S. Imai; I. Urasinski; M. De Bruyére; V. Ferrer Argote; J. Krueger

doi:10.1159/000030986

Comparison of seroprevalences of human herpesvirus-6 and -7 in healthy blood donors from nine countries

Gerhard R.F. Krueger, B. Koch, N. Leyssens, Z. Berneman, J. Rojo, C. Horwitz, T. Sloots, M. Margalith, J. D. Conradie, S. Imai, I. Urasinski, M. De Bruyére, V. Ferrer Argote, J. Krueger

Virology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Background and Objectives: The purpose of the study was to register antibody prevalences of HHV-7 in various locations of the world in comparison to the closely related HHV-6. Materials and Methods: Sera of healthy blood donors from nine countries in five continents were titered by indirect immunofluorescent assays using HHV-6 infected HSB2 and HHV-7 infected SupT1 cells. Results: Antibody prevalence for HHV-7 is high (75-98%) in practically all countries except for Northern Japan (44%), with no simple correlation to elevated HHV-6 antibody titers. There were regions of low, intermediate and high mean antibody titers against HHV-7 such as 78.5-91.3 for Belgium, Israel, Japan, USA and Australia, 175.4-182.6 for Mexico and Cologne/Germany, and 389.2 for South Africa for which geographic characteristics may be responsible. Conclusion: HHV-7, similar to HHV-6, is a widespread human herpesvirus with elevated antibody titers in the healthy human population essentially everywhere. The data warrant further studies to evaluate its possible pathologic potential, preferentially in persons with defective immune responses.

Original language	English
Pages (from-to)	193-197
Number of pages	5
Journal	Vox Sanguinis
Volume	75
Issue number	3
DOIs	https://doi.org/10.1159/000030986
State	Published - 1 Jan 1998

ASJC Scopus subject areas

Hematology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000030986

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Krueger, G. R. F., Koch, B., Leyssens, N., Berneman, Z., Rojo, J., Horwitz, C., Sloots, T., Margalith, M., Conradie, J. D., Imai, S., Urasinski, I., De Bruyére, M., Argote, V. F., & Krueger, J. (1998). Comparison of seroprevalences of human herpesvirus-6 and -7 in healthy blood donors from nine countries. Vox Sanguinis, 75(3), 193-197. https://doi.org/10.1159/000030986

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title = "Comparison of seroprevalences of human herpesvirus-6 and -7 in healthy blood donors from nine countries",

abstract = "Background and Objectives: The purpose of the study was to register antibody prevalences of HHV-7 in various locations of the world in comparison to the closely related HHV-6. Materials and Methods: Sera of healthy blood donors from nine countries in five continents were titered by indirect immunofluorescent assays using HHV-6 infected HSB2 and HHV-7 infected SupT1 cells. Results: Antibody prevalence for HHV-7 is high (75-98%) in practically all countries except for Northern Japan (44%), with no simple correlation to elevated HHV-6 antibody titers. There were regions of low, intermediate and high mean antibody titers against HHV-7 such as 78.5-91.3 for Belgium, Israel, Japan, USA and Australia, 175.4-182.6 for Mexico and Cologne/Germany, and 389.2 for South Africa for which geographic characteristics may be responsible. Conclusion: HHV-7, similar to HHV-6, is a widespread human herpesvirus with elevated antibody titers in the healthy human population essentially everywhere. The data warrant further studies to evaluate its possible pathologic potential, preferentially in persons with defective immune responses.",

author = "Krueger, {Gerhard R.F.} and B. Koch and N. Leyssens and Z. Berneman and J. Rojo and C. Horwitz and T. Sloots and M. Margalith and Conradie, {J. D.} and S. Imai and I. Urasinski and {De Bruy{\'e}re}, M. and Argote, {V. Ferrer} and J. Krueger",

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AU - Krueger, Gerhard R.F.

AU - Koch, B.

AU - Leyssens, N.

AU - Berneman, Z.

AU - Rojo, J.

AU - Horwitz, C.

AU - Sloots, T.

AU - Margalith, M.

AU - Conradie, J. D.

AU - Imai, S.

AU - Urasinski, I.

AU - De Bruyére, M.

AU - Argote, V. Ferrer

AU - Krueger, J.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Background and Objectives: The purpose of the study was to register antibody prevalences of HHV-7 in various locations of the world in comparison to the closely related HHV-6. Materials and Methods: Sera of healthy blood donors from nine countries in five continents were titered by indirect immunofluorescent assays using HHV-6 infected HSB2 and HHV-7 infected SupT1 cells. Results: Antibody prevalence for HHV-7 is high (75-98%) in practically all countries except for Northern Japan (44%), with no simple correlation to elevated HHV-6 antibody titers. There were regions of low, intermediate and high mean antibody titers against HHV-7 such as 78.5-91.3 for Belgium, Israel, Japan, USA and Australia, 175.4-182.6 for Mexico and Cologne/Germany, and 389.2 for South Africa for which geographic characteristics may be responsible. Conclusion: HHV-7, similar to HHV-6, is a widespread human herpesvirus with elevated antibody titers in the healthy human population essentially everywhere. The data warrant further studies to evaluate its possible pathologic potential, preferentially in persons with defective immune responses.

AB - Background and Objectives: The purpose of the study was to register antibody prevalences of HHV-7 in various locations of the world in comparison to the closely related HHV-6. Materials and Methods: Sera of healthy blood donors from nine countries in five continents were titered by indirect immunofluorescent assays using HHV-6 infected HSB2 and HHV-7 infected SupT1 cells. Results: Antibody prevalence for HHV-7 is high (75-98%) in practically all countries except for Northern Japan (44%), with no simple correlation to elevated HHV-6 antibody titers. There were regions of low, intermediate and high mean antibody titers against HHV-7 such as 78.5-91.3 for Belgium, Israel, Japan, USA and Australia, 175.4-182.6 for Mexico and Cologne/Germany, and 389.2 for South Africa for which geographic characteristics may be responsible. Conclusion: HHV-7, similar to HHV-6, is a widespread human herpesvirus with elevated antibody titers in the healthy human population essentially everywhere. The data warrant further studies to evaluate its possible pathologic potential, preferentially in persons with defective immune responses.

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Comparison of seroprevalences of human herpesvirus-6 and -7 in healthy blood donors from nine countries

Abstract

ASJC Scopus subject areas

UN SDGs

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