Comparison of the distribution of parvalbumin-immunoreactive and other synapses onto the somata of callosal projection neurons in mouse visual and somatosensory cortex

David Czeiger, Edward L. White

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The distribution of synapses made by parvalbumin-immunoreactive (pv-ir) and nonimmunoreactive terminals was determined for the cell bodies of callosal projection neurons in the somatosensory and visual areas of mouse cerebral cortex. Callosal neurons were labeled by the retrograde transport of horseradish peroxidase applied to the contralateral hemisphere. The surface areas of somata belonging to callosal cells in somatosensory cortex ranged from 230 to 243 μm2 in size and received roughly one-third of their synapses from pv-ir terminals. Visual cortex, in contrast, contained two populations of callosal cell bodies: relatively large ones ranging in size from 255 to 279 μm2 that received 3-9% of their synapses from large terminals and smaller cell bodies that both in size (232-237 μm2) and in the proportion of synapses received from pv-ir terminals resemble the callosal cells examined in somatosensory cortex. That different functional areas of the cortex have populations of callosal cells similar in size, and displaying similar patterns of somatic synapses, supports the notion that a common plan of synaptic connectivity characterizes different functional areas. Results in visual cortex indicate that functional areas contain, in addition, area-specific patterns of synapses.

Original languageEnglish
Pages (from-to)198-210
Number of pages13
JournalJournal of Comparative Neurology
Volume379
Issue number2
DOIs
StatePublished - 10 Mar 1997

Keywords

  • callosum
  • cerebral cortex
  • horseradish peroxidase
  • immunolabeling
  • silver/gold intensification

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