Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions

Keyphrases

• Sclerostin 100%
• Binding Interface 100%
• Bone Anabolic Effects 100%
• Competitive Blocking 100%
• LRP4 80%
• Wnt Signaling Pathway 40%
• LRP6 30%
• Lipoprotein Receptor-related Protein 20%
• Subcutaneous Injection 10%
• Antagonistic Activity 10%
• Binding Site 10%
• Developing Mice 10%
• Bone Formation 10%
• Trabecular Bone 10%
• Immunoglobulin 10%
• Osteoblast 10%
• Binding Affinity 10%
• Co-receptor 10%
• Bone Size 10%
• Stronger Binding 10%
• Yeast Surface Display 10%
• Fragment Crystallizable 10%
• Display System 10%
• Wnt Ligands 10%
• Osteocyte 10%
• Low-density Lipoprotein Receptor-related Protein 5 (LRP5) 10%
• Bone Formation Rate 10%
• Trabecular number 10%
• Low-density Lipoprotein Receptor-related Protein 6 10%

Biochemistry, Genetics and Molecular Biology

• Sclerostin 100%
• Wnt Signaling Pathway 40%
• Lipoprotein Receptor-Related Protein 30%
• LRP6 30%
• Ossification 20%
• Mouse 10%
• Intravenous Immunoglobulin 10%
• Binding Site 10%
• Binding Affinity 10%
• Osteoblast 10%
• LDL Receptor 10%
• Co-Receptor 10%
• Yeast Display 10%
• Osteocyte 10%