COMPOSITIONS AND METHODS FOR IN VITRO SORTING OF MOLECULAR AND CELLULAR LIBRARIES

Dan Tawfik; Kalia Bernath; Amir Aharoni; Sergio Peisajovich; D Griffiths, Andrew; Enrico Mastrobattista; Shlomo Magdassi

COMPOSITIONS AND METHODS FOR IN VITRO SORTING OF MOLECULAR AND CELLULAR LIBRARIES

Dan Tawfik (Inventor), Kalia Bernath (Inventor), Amir Aharoni (Inventor), Sergio Peisajovich (Inventor), D Griffiths, Andrew (Inventor), Enrico Mastrobattista (Inventor), Shlomo Magdassi (Inventor)

Department of Life Sciences

Research output: Patent

Abstract

The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water-in-oil-in-water emulsion. The emulation includes a continuous external aqueous phase and a discontinuous dispersion of water-in-oil droplets. The internal aqueous phase of a plurality of such droplets comprises a specific molecule or cell that is within the plurality of distinct molecules or cells of the library.

Original language	English
Patent number	WO2005049787
IPC	C40B 40/ 08 A I
Priority date	13/10/04
State	Published - 2 Jun 2005

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title = "COMPOSITIONS AND METHODS FOR IN VITRO SORTING OF MOLECULAR AND CELLULAR LIBRARIES",

abstract = "The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water-in-oil-in-water emulsion. The emulation includes a continuous external aqueous phase and a discontinuous dispersion of water-in-oil droplets. The internal aqueous phase of a plurality of such droplets comprises a specific molecule or cell that is within the plurality of distinct molecules or cells of the library.",

author = "Dan Tawfik and Kalia Bernath and Amir Aharoni and Sergio Peisajovich and {Griffiths, Andrew}, D and Enrico Mastrobattista and Shlomo Magdassi",

year = "2005",

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day = "2",

language = "English",

type = "Patent",

note = "WO2005049787; C40B 40/ 08 A I",

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TY - PAT

T1 - COMPOSITIONS AND METHODS FOR IN VITRO SORTING OF MOLECULAR AND CELLULAR LIBRARIES

AU - Tawfik, Dan

AU - Bernath, Kalia

AU - Aharoni, Amir

AU - Peisajovich, Sergio

AU - Griffiths, Andrew, D

AU - Mastrobattista, Enrico

AU - Magdassi, Shlomo

PY - 2005/6/2

Y1 - 2005/6/2

N2 - The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water-in-oil-in-water emulsion. The emulation includes a continuous external aqueous phase and a discontinuous dispersion of water-in-oil droplets. The internal aqueous phase of a plurality of such droplets comprises a specific molecule or cell that is within the plurality of distinct molecules or cells of the library.

AB - The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water-in-oil-in-water emulsion. The emulation includes a continuous external aqueous phase and a discontinuous dispersion of water-in-oil droplets. The internal aqueous phase of a plurality of such droplets comprises a specific molecule or cell that is within the plurality of distinct molecules or cells of the library.

M3 - Patent

M1 - WO2005049787

ER -

COMPOSITIONS AND METHODS FOR IN VITRO SORTING OF MOLECULAR AND CELLULAR LIBRARIES

Abstract

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