Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids

Farren Isaacs (Inventor), Miriam Amiram (Inventor), Adrian Haimovich (Inventor), Dieter Soll (Inventor)

Research output: Patent

Abstract

Compositions, systems, and methods for preparation of polypeptides having multiple iterations of non-standard amino acids are provided. The compositions and method can be used to produce recombinant proteins at a greater yield than the same or similar polypeptides made using conventional compositions, systems, and methods. Accordingly, in some embodiments, the polypeptides are ones that could not be made using conventional methods and reagents, or could not be made a sufficient yield or purity to serve a practical purpose using conventional methods and reagents. Polypeptides made using the disclosed compositions, systems, and methods are also provided.
Original languageEnglish
Patent numberUS20200190500A1
StatePublished - 1 Jun 2020

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