COMPOSITIONS OF HSP60 PEPTIDES AND VIRAL ANTIGENS FOR VACCINATION AND DIAGNOSIS

Irun R Cohen (Inventor), Bracha Rager-Zisman (Inventor), Angel Porgador (Inventor), Johannes Herkel (Inventor)

Research output: Patent

Abstract

The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses.

Original languageEnglish
Patent numberUS2011256165
IPCG01N 33/ 566 A I
Priority date20/06/11
StatePublished - 20 Oct 2011

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