Verified and validated simulations of the mechanical response of femurs, based on CT scans, have been recently presented. These simulations, based on highorder finite element methods (p-FEMs), may be used to diagnose the risk or fracture when used in clinical orthopedic practice. The first part of this chapter describes the methods used to create p-FEM models of patient-specific femurs and the in-vitro experiments used to assess the validity of the simulation results. Having demonstrated that p-FEMs using CT-scans allow personalized assessment of the risk of fracture of a given femur, we envision a simulation center that may serve a large community of orthopedic doctors, each submitting a CT-scan to be analysed. In such a situation, multiple p-FE models must be simultaneously generated, solved and the verified FE results must be returned to the interested orthopedists. Because such analyses are sought in a short time-scale, and the interaction with the orthopedists will be by mobile devices in the future, we present the implementation of a multi-threaded p-FE solver in the second half of the chapter that will perform multiple solutions simultaneously.