Conformation of the oligonucleotide d(AAAAAATTTTTT)2 by two‐dimensional nuclear overhauser effect spectroscopy and its relevance to poly(dA) · poly(dT)

Siddhartha Roy; Babul Borah; Gerald Zon; Jack S. Cohen

doi:10.1002/bip.360260406

Conformation of the oligonucleotide d(AAAAAATTTTTT)₂ by two‐dimensional nuclear overhauser effect spectroscopy and its relevance to poly(dA) · poly(dT)

Siddhartha Roy, Babul Borah, Gerald Zon, Jack S. Cohen

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Conformational analysis from the pattern and intensities of cross‐peaks in the two‐dimensional nuclear Overhauser effect proton nmr spectra of the homopolymer, poly(dA) · poly(dT), and the analogous oligomer, d(AAAAAATTTTTT)₂, indicate that they both exist in the B‐conformation. The conformation of the ApT/TpA junction in the oligomer is significantly different from the rest of the base pairs.

Original language	English
Pages (from-to)	525-536
Number of pages	12
Journal	Biopolymers
Volume	26
Issue number	4
DOIs	https://doi.org/10.1002/bip.360260406
State	Published - 1 Jan 1987
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Biomaterials
Organic Chemistry

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AB - Conformational analysis from the pattern and intensities of cross‐peaks in the two‐dimensional nuclear Overhauser effect proton nmr spectra of the homopolymer, poly(dA) · poly(dT), and the analogous oligomer, d(AAAAAATTTTTT)2, indicate that they both exist in the B‐conformation. The conformation of the ApT/TpA junction in the oligomer is significantly different from the rest of the base pairs.

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Conformation of the oligonucleotide d(AAAAAATTTTTT)₂ by two‐dimensional nuclear overhauser effect spectroscopy and its relevance to poly(dA) · poly(dT)

Abstract

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