Congenital malformations and anticonvulsant therapy in pregnancy

P. Shvartzman, B. Oren, H. Adar, A. Keinen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In a retrospective survey of the outcome of 44 pregnancies in 14 epileptic women under anticonvulsant treatment, a high frequency of congenital malformations was found. 48% of the children with abnormalities had cardiovascular lesions, 45% skeletal, and 25% urogenital; other minor abnormalities were also found. However, in eight pregnancies in which epileptic mothers did not receive anticonvulsants there were very few congenital malformations. This survey revealed a higher incidence of malformations than that described in the literature, a fact for which the authors have no explanation. Their results justify the inclusion of the pregnant epileptic woman getting anticonvulsants in the high risk pregnancy group and she should have gynecological, neurological and pediatric supervision. The authors still have no answer to the difficult dilemma of what is preferable, epileptic fits during pregnancy or the possible teratogenic effects of anticonvulsant drugs.

Original languageEnglish
Pages (from-to)377-380+430
JournalHarefuah
Volume110
Issue number8
StatePublished - 1 Dec 1986
Externally publishedYes

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