Continuous venovenous hemofiltration improves intensive care unit, but not hospital survival rate, in nonoliguric septic patients

Natan Weksler, Illia Chorni, Gabriel M. Gurman, Aviel R. Shapira, Lazaro Gotloib

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Purpose: The purpose of this study was to assess the effect of the early institution of continuous venovenous hemofiltration on survival rates of nonoliguric, septic patients. Materials and Methods: A retrospective study of 48 nonoliguric septic patients with Pao2/Fio2 ≤ 250, who were admitted to the General Intensive Care of the Soroka Medical Center. Twenty-six patients were treated with continuous venovenous hemofiltration (CVVH group) and 22 were treated by conventional therapy. The end point of treatment was weaning from mechanical ventilation, adequate oxygenation, and the need for minimal cardiocirculatory support. Results: The study groups were similar in terms of age, gender, percentage of surgical or nonsurgical patients, APACHE II scores, and the Therapeutic Intervention Scoring System (TISS). Baseline serum urea and creatinine levels were similar in the groups, but the PAO2/FlO2 ratio was significantly lower in the CVVH group (150.6 ± 86 vs. 214.2 ± 8.9).Twenty of the CVVH patients and 10 of the patients receiving conventional therapy were discharged from the intensive care unit (P = .03), but the hospital discharge rate was only slightly higher in the CVVH group (12 of 26) compared with the conventional therapy group (7 of 22) (P = .145). Conclusions: In this retrospective uncontrolled study, the mortality rate was considerably lower in nonoliguric septic patients who received continuous venovenous hemofiltration early in the course of the disease. The improved survival rate may be due to the ability of CVVH to eliminate mediators involved in the septic process, thus averting the multiple system organ failure consequent to septic insult.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalJournal of Critical Care
Issue number2
StatePublished - 1 Jan 2001
Externally publishedYes

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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