Control of Streptococcus pneumoniae serotype 5 epidemic of severe pneumonia among young army recruits by mass antibiotic treatment and vaccination

Ran Balicer, Salman Zarka, Hagai Levine, Eyal Klement, Tamar Sela, Nurit Porat, Nachman Ash, Ron Dagan

    Research output: Contribution to journalArticlepeer-review

    29 Scopus citations

    Abstract

    During an outbreak of severe pneumonia among new army recruits, an epidemiological investigation combined with repeated nasopharyngeal/oropharyngeal cultures from sick and healthy contacts subjects was conducted. Fifteen pneumonia cases and 19 influenza-like illness cases occurred among 596 recruits over a 4-week period in December 2005. Pneumonia attack rates reached up to 5.5%. A single pneumococcus serotype 5 clone was isolated from blood or sputum cultures in 4 patients and 30/124 (24.1%) contacts. Immunization with 23-valent polysaccharide vaccine supplemented with a 2-dose azithromycin mass treatment rapidly terminated the outbreak. Carriage rates dropped to <1%, 24 and 45 days after intervention.

    Original languageEnglish
    Pages (from-to)5591-5596
    Number of pages6
    JournalVaccine
    Volume28
    Issue number34
    DOIs
    StatePublished - 1 Aug 2010

    Keywords

    • Carriage
    • Outbreak
    • Pneumonia
    • Streptococcus pneumoniae
    • Vaccine
    • Young adults

    ASJC Scopus subject areas

    • Molecular Medicine
    • Immunology and Microbiology (all)
    • Veterinary (all)
    • Public Health, Environmental and Occupational Health
    • Infectious Diseases

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