Controlled drug release characteristics and enhanced antibacterial effect of graphene nanosheets containing gentamicin sulfate

Himanshu Pandey; Vyom Parashar; Rashmi Parashar; Rajiv Prakash; Promod W. Ramteke; Avinash C. Pandey

doi:10.1039/c1nr10661a

Controlled drug release characteristics and enhanced antibacterial effect of graphene nanosheets containing gentamicin sulfate

Himanshu Pandey, Vyom Parashar, Rashmi Parashar, Rajiv Prakash, Promod W. Ramteke, Avinash C. Pandey

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

A novel methanol derived graphene (MDG) and gentamicin sulfate nanohybrid was prepared, and the loading and release behaviour of gentamicin on MDG is investigated. An efficient drug loading of 2.57 mg mg^-1 was obtained at pH 7. By applying release kinetic models, the mechanism of release of the drug from the MDG matrix was found to be following the Korsmeyer-Peppas model. However, the diffusional release exponent (n) value lies below 0.5 demonstrating that the mechanism controlling the drug release is the Fickian diffusion.

Original language	English
Pages (from-to)	4104-4108
Number of pages	5
Journal	Nanoscale
Volume	3
Issue number	10
DOIs	https://doi.org/10.1039/c1nr10661a
State	Published - 1 Oct 2011
Externally published	Yes

ASJC Scopus subject areas

General Materials Science

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abstract = "A novel methanol derived graphene (MDG) and gentamicin sulfate nanohybrid was prepared, and the loading and release behaviour of gentamicin on MDG is investigated. An efficient drug loading of 2.57 mg mg-1 was obtained at pH 7. By applying release kinetic models, the mechanism of release of the drug from the MDG matrix was found to be following the Korsmeyer-Peppas model. However, the diffusional release exponent (n) value lies below 0.5 demonstrating that the mechanism controlling the drug release is the Fickian diffusion.",

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AU - Prakash, Rajiv

AU - Ramteke, Promod W.

AU - Pandey, Avinash C.

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AB - A novel methanol derived graphene (MDG) and gentamicin sulfate nanohybrid was prepared, and the loading and release behaviour of gentamicin on MDG is investigated. An efficient drug loading of 2.57 mg mg-1 was obtained at pH 7. By applying release kinetic models, the mechanism of release of the drug from the MDG matrix was found to be following the Korsmeyer-Peppas model. However, the diffusional release exponent (n) value lies below 0.5 demonstrating that the mechanism controlling the drug release is the Fickian diffusion.

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Controlled drug release characteristics and enhanced antibacterial effect of graphene nanosheets containing gentamicin sulfate

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