Abstract
As You Like It: The convergent chemical synthesis of the histone H2B protein was achieved. This approach enabled the attachment of ubiquitin at Lys34 (see picture) and should make it possible to synthesize H2B with any other posttranslational modification in demand.
Original language | English |
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Pages (from-to) | 8059-8063 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 52 |
Issue number | 31 |
DOIs | |
State | Published - 29 Jul 2013 |
Keywords
- H2B protein
- chromatin
- peptide ligation
- proteins
- ubiquitination
ASJC Scopus subject areas
- Catalysis
- General Chemistry