Converting heterodimeric gonadotropins to genetically linked single chains: New approaches to structure activity relationships and analogue design

David Ben-Menahem, Irving Boime

Research output: Contribution to journalShort surveypeer-review

26 Scopus citations

Abstract

One of the distinguishing features of the gonadotropin and thyrotropin hormone family is their heterodimeric structure; the subunits combine early in the secretory pathway and only the dimers are capable of binding to receptors. Therefore, assembly is rate limiting in the production of functional heterodimers, a problem encountered when removing the carbohydrates from one or both subunits as discussed in this review. If the heterodimers can be expressed as single chains, this might avoid mutagenesis- induced defects in secretion and combination of individual subunits for structure-function studies and analogue design. Here we discuss the feasibility of this approach for such problems.

Original languageEnglish
Pages (from-to)100-105
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume7
Issue number3
DOIs
StatePublished - 1 Jan 1996
Externally publishedYes

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