Many studies have examined the coping strategies and depression of mothers of children with disabilities, but most have involved Western families and only a few refer to unique and traditional cultures. The main goal of the current study was to assess depression among Bedouin Israeli mothers raising children with developmental disability (DD) and how it is linked to their coping strategies. The study included a sample of 95 Bedouin mothers of adolescents with and without DD in Israel. Self-report measures of CES-D and Brief Cope were used to measure depression and coping strategies. Findings revealed an alarmingly high prevalence of severe depression among Bedouin mothers, especially among those raising a child with DD. Mothers raising a child with a developmental disability tended to use avoidant coping more often, while the use of active coping strategies did not differ between the two groups. Adaptivity of planning and behavioral disengagement was found to be context dependent. Findings underscore the vulnerability of Bedouin mothers living in Israel, and particularly Bedouin mothers raising a child with a DD which are a double jeopardy group.