Copper-catalyzed cross-coupling of sulfonyl hydrazides with aryl hydrazines to synthesize diaryl sulfones

E. V.Venkat Shivaji Ramarao; Jayshree Solanke; Rana Chatterjee; Rambabu Dandela

doi:10.1016/j.tetlet.2025.155845

Copper-catalyzed cross-coupling of sulfonyl hydrazides with aryl hydrazines to synthesize diaryl sulfones

E. V.Venkat Shivaji Ramarao
, Jayshree Solanke
, Rana Chatterjee
, Rambabu Dandela

Research output: Contribution to journal › Article › peer-review

Abstract

A simple and efficient method for the construction of symmetrical and unsymmetrical diaryl sulfones has been developed. Herein, Cu(OAc)₂-catalyzed oxidative cross-coupling of aryl sulfonyl hydrazides and aryl hydrazine easily afforded the diaryl sulfones in the presence of K₂CO₃ base and DMSO medium. Notably, a variety of diaryl sulfone derivatives have been synthesized in moderate to good yields.

Original language	English
Article number	155845
Journal	Tetrahedron Letters
Volume	174
DOIs	https://doi.org/10.1016/j.tetlet.2025.155845
State	Published - 15 Jan 2026
Externally published	Yes

Keywords

C(sp2) − S bond formation.
Copper catalysis
Diaryl sulfones
Oxidative cross-coupling
Sulfonyl hydrazides

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2025.155845

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title = "Copper-catalyzed cross-coupling of sulfonyl hydrazides with aryl hydrazines to synthesize diaryl sulfones",

abstract = "A simple and efficient method for the construction of symmetrical and unsymmetrical diaryl sulfones has been developed. Herein, Cu(OAc)2-catalyzed oxidative cross-coupling of aryl sulfonyl hydrazides and aryl hydrazine easily afforded the diaryl sulfones in the presence of K2CO3 base and DMSO medium. Notably, a variety of diaryl sulfone derivatives have been synthesized in moderate to good yields.",

keywords = "C(sp2) − S bond formation., Copper catalysis, Diaryl sulfones, Oxidative cross-coupling, Sulfonyl hydrazides",

author = "Ramarao, \{E. V.Venkat Shivaji\} and Jayshree Solanke and Rana Chatterjee and Rambabu Dandela",

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year = "2026",

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doi = "10.1016/j.tetlet.2025.155845",

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T1 - Copper-catalyzed cross-coupling of sulfonyl hydrazides with aryl hydrazines to synthesize diaryl sulfones

AU - Ramarao, E. V.Venkat Shivaji

AU - Solanke, Jayshree

AU - Chatterjee, Rana

AU - Dandela, Rambabu

PY - 2026/1/15

Y1 - 2026/1/15

N2 - A simple and efficient method for the construction of symmetrical and unsymmetrical diaryl sulfones has been developed. Herein, Cu(OAc)2-catalyzed oxidative cross-coupling of aryl sulfonyl hydrazides and aryl hydrazine easily afforded the diaryl sulfones in the presence of K2CO3 base and DMSO medium. Notably, a variety of diaryl sulfone derivatives have been synthesized in moderate to good yields.

AB - A simple and efficient method for the construction of symmetrical and unsymmetrical diaryl sulfones has been developed. Herein, Cu(OAc)2-catalyzed oxidative cross-coupling of aryl sulfonyl hydrazides and aryl hydrazine easily afforded the diaryl sulfones in the presence of K2CO3 base and DMSO medium. Notably, a variety of diaryl sulfone derivatives have been synthesized in moderate to good yields.

KW - C(sp2) − S bond formation.

KW - Copper catalysis

KW - Diaryl sulfones

KW - Oxidative cross-coupling

KW - Sulfonyl hydrazides

UR - https://www.scopus.com/pages/publications/105020924747

U2 - 10.1016/j.tetlet.2025.155845

DO - 10.1016/j.tetlet.2025.155845

M3 - Article

AN - SCOPUS:105020924747

SN - 0040-4039

VL - 174

JO - Tetrahedron Letters

JF - Tetrahedron Letters

M1 - 155845

ER -

Copper-catalyzed cross-coupling of sulfonyl hydrazides with aryl hydrazines to synthesize diaryl sulfones

Abstract

Keywords

ASJC Scopus subject areas

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