Copper metabolism - a factor in gestational diabetes?

A. Loven, Y. Romem, I. Z. Pelly, G. Holcberg, G. Agam

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The purpose of the present work was to investigate whether there is an involvement of copper metabolism in the mechanism of gestational diabetes mellitus. No statistically significant differences were found in serum copper and ceruloplasmin concentrations between healthy pregnant women and women with gestational diabetes mellitus. The activity of ceruloplasmin in women with gestational diabetes mellitus was slightly higher and its specific activity significantly raised. The CuZn Superoxide dismutase activity was significantly increased (P < 0.05) in women with gestational diabetes mellitus, comparing the two groups by matched pairs according to age. The results indicate that oxidative stress may have a role in gestational diabetes mellitus and that reduced concentrations of copper are not the cause of this stress.

Original languageEnglish
Pages (from-to)51-59
Number of pages9
JournalClinica Chimica Acta
Volume213
Issue number1-3
DOIs
StatePublished - 31 Dec 1992

Keywords

  • Erythrocyte CuZn-superoxide dismutase
  • Gestational diabetes
  • Serum copper and ceruloplasmin

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