Corneal staining after treatment with topical tetracycline

Ruth Lapid-Gortzak, Carla P. Nieuwendaal, Allan R. Slomovic, Lodewijk Spanjaard

Research output: Contribution to journalArticlepeer-review


PURPOSE: The purpose of this paper is to report a case of corneal staining after treatment with topical tetracycline. METHODS: A patient with crystalline keratopathy caused by Streptococcus viridans after corneal transplantation was treated topically with tetracycline eye drops, based on results of bacterial sensitivity testing. After 3 weeks of intensive treatment, the donor cornea was stained with a brownish hue, which was ascribed to the tetracycline drops. RESULTS: One patient with crystalline keratopathy developed corneal staining after intensive treatment with topical tetracycline eye drops. After a year of follow-up, the staining of the cornea had not changed significantly. CONCLUSION: Hourly topical tetracycline eye drops may induce corneal pigmentation. To our knowledge, this is the first published case report of corneal staining caused by tetracycline eye drops.

Original languageEnglish
Pages (from-to)969-970
Number of pages2
Issue number8
StatePublished - 1 Nov 2006
Externally publishedYes


  • Corneal staining
  • Side effect
  • Tetracycline eye drops

ASJC Scopus subject areas

  • Ophthalmology


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