Correlative links between superoxide dismutase, catalase, and glutathione peroxidase activities in the liver of mice

K. K. Muradian, N. A. Utko, T. G. Mozzhukhina, I. N. Pishel, A. Ya Litoshenko, V. V. Bezrukov, V. E. Fraifeld

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Qualitative and quantitative differences in correlative and regressive links between superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase were assessed in the mice liver by two- and three-dimensional statistical methods. Paired linear correlation analysis indicated SOD-CAT tandem as the correlatively acting enzymatic pair. Three-dimensional analysis revealed uniform response surfaces which exhibited higher activities at disproportional values of the other two and lower activities at proportional activities of the other two enzymes. The direct effect of the enzymes on each other was posilive while the effect of their product was always negative.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalUkrainian Biochemical Journal
Volume75
Issue number1
StatePublished - 20 Nov 2003
Externally publishedYes

Keywords

  • Catalase
  • Glutathione peroxidase
  • Liver
  • Mice
  • Superoxide dismutase

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