Corrosion Characteristics Dictate the Long-Term Inflammatory Profile of Degradable Zinc Arterial Implants

Roger J. Guillory, Patrick K. Bowen, Sean P. Hopkins, Emily R. Shearier, Elisha J. Earley, Amani A. Gillette, Eli Aghion, Martin Bocks, Jaroslaw W. Drelich, Jeremy Goldman

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

There has been considerable recent interest to develop a feasible bioresorbable stent (BRS) metal. Although zinc and its alloys have many potential advantages, the inflammatory response has not been carefully examined. Using a modified wire implantation model, we characterize the inflammatory response elicited by zinc at high purity (4N) [99.99%], special high grade (SHG)[∼99.7%], and alloyed with 1 wt % (Zn-1Al), 3% (Zn-3Al), and 5.5% (Zn-5Al) aluminum. We found that inflammatory cells were able to penetrate the thick and porous corrosion layer that quickly formed around SHG, Zn-1Al, Zn-3Al, and Zn-5Al implants. In contrast, a delayed entrance of inflammatory cells into the corrosion layer around 4N zinc due to a significantly lower corrosion rate was associated with greater fibrous encapsulation, appearance of necrotic regions, and increased macrophage labeling. Interestingly, cell viability at the interface decreased from SHG, to Zn-1Al, and then Zn-3Al, a trend associated with an increased CD68 and CD11b labeling and capsule thickness. Potentially, the shift to intergranular corrosion due to the aluminum addition increased the activity of macrophages. We conclude that the ability of macrophages to penetrate and remain viable within the corrosion layer may be of fundamental importance for eliciting biocompatible inflammatory responses around corrodible metals.

Original languageEnglish
Pages (from-to)2355-2364
Number of pages10
JournalACS Biomaterials Science and Engineering
Volume2
Issue number12
DOIs
StatePublished - 12 Dec 2016

Keywords

  • corrosion
  • degradable
  • inflammation
  • stents
  • zinc

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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