Corticosteroids do not affect the clinical or physiological status of infants with bronchiolitis

Chaim Springer, Ephraim Bar‐Yishay, Kamal Uwayyed, Avraham Avital, Daphna Vilozni, Simon Godfrey

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

The treatment of infants aged 1.5–11.0 months suffering from acute bronchiolitis with a combination of inhaled albuterol and systemic corticosteroids or inhaled albuterol and placebo was compared in 50 infants in a double blind study. The mean initial clinical score and the rate of improvement was similar in the two groups. The mean ± SD hospital stay was 5.0 ± 1.2 days for the steroid group and 5.2 ± 1.7 days for the placebo group. Lung function was measured in 14 infants (7 from each group) and showed evidence of increased lung volumes and severe airway obstruction in the acute stage (the mean values for the steroid group were: TGV, 31 mL/kg; SGaw, 0.104 L/s·cmH2O; V̇maxFRC, 12.9 mL/s/kg; for the placebo group: TGV, 35 mL/kg; SGaw, 0.104 L/s·cmH2O; V̇maxFRC, 8.5 mL/s/kg) which had improved 2–4 weeks later (steroid group: TGV, 25 mL/kg; SGaw, 0.168 L/s·cmH2O; V̇maxFRC, 21.6 mL/s/kg; –placebo group: TGV, 24 mL/kg, SGaw, 0.198 L/s·cmH2O, V̇maxFRC, 17.5 mL/s/kg). There were no significant differences of thoracic gas volume, specific airway conductance, and forced expiratory flow at resting lung volume between the two groups, either in the acute or convalescent stages. We conclude that corticosteroids do not change the rate of clinical improvement in acute bronchiolitis, nor do they effect lung function 2–4 weeks later. Pediatr Pulmonal 1990; 9:181–185.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalPediatric Pulmonology
Volume9
Issue number3
DOIs
StatePublished - 1 Jan 1990
Externally publishedYes

Keywords

  • 2–4 weeks follow‐up
  • Hydrocortisone IV
  • acute bronchiolitis
  • clinical score
  • inhaled alburterol
  • prednisone PO
  • pulmonary function

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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