Covalently linked DNA nanotubes

Ofer I. Wilner; Anja Henning; Bella Shlyahovsky; Itamar Willner

doi:10.1021/nl100389v

Covalently linked DNA nanotubes

Ofer I. Wilner, Anja Henning, Bella Shlyahovsky, Itamar Willner

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The present study introduces an approach to prepare covalently linked DNA nanotubes. A circular DNA that includes at its opposite poles thiol and amine functionalities acts as the building block for the construction of the DNA nanotubes. The circular DNA is cross-linked with a bis-amide-modified nucleic acid to yield DNA nanowires, and these are subsequently cross-linked by a bis-thiolated nucleic acid to yield the DNA nanotubes. Alternatively, a circular DNA that includes four amine functionalities on its poles is cross-linked in one-step by the bis-thiolated nucleic acid to yield the nanotubes. The resulting nanostructures are stable and nonseparable upon heating.

Original language	English
Pages (from-to)	1458-1465
Number of pages	8
Journal	Nano Letters
Volume	10
Issue number	4
DOIs	https://doi.org/10.1021/nl100389v
State	Published - 14 Apr 2010
Externally published	Yes

Keywords

DNA
Nanotubes
Nanowires
Nucleic acids
Self-assembly

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl100389v

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abstract = "The present study introduces an approach to prepare covalently linked DNA nanotubes. A circular DNA that includes at its opposite poles thiol and amine functionalities acts as the building block for the construction of the DNA nanotubes. The circular DNA is cross-linked with a bis-amide-modified nucleic acid to yield DNA nanowires, and these are subsequently cross-linked by a bis-thiolated nucleic acid to yield the DNA nanotubes. Alternatively, a circular DNA that includes four amine functionalities on its poles is cross-linked in one-step by the bis-thiolated nucleic acid to yield the nanotubes. The resulting nanostructures are stable and nonseparable upon heating.",

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AU - Henning, Anja

AU - Shlyahovsky, Bella

AU - Willner, Itamar

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N2 - The present study introduces an approach to prepare covalently linked DNA nanotubes. A circular DNA that includes at its opposite poles thiol and amine functionalities acts as the building block for the construction of the DNA nanotubes. The circular DNA is cross-linked with a bis-amide-modified nucleic acid to yield DNA nanowires, and these are subsequently cross-linked by a bis-thiolated nucleic acid to yield the DNA nanotubes. Alternatively, a circular DNA that includes four amine functionalities on its poles is cross-linked in one-step by the bis-thiolated nucleic acid to yield the nanotubes. The resulting nanostructures are stable and nonseparable upon heating.

AB - The present study introduces an approach to prepare covalently linked DNA nanotubes. A circular DNA that includes at its opposite poles thiol and amine functionalities acts as the building block for the construction of the DNA nanotubes. The circular DNA is cross-linked with a bis-amide-modified nucleic acid to yield DNA nanowires, and these are subsequently cross-linked by a bis-thiolated nucleic acid to yield the DNA nanotubes. Alternatively, a circular DNA that includes four amine functionalities on its poles is cross-linked in one-step by the bis-thiolated nucleic acid to yield the nanotubes. The resulting nanostructures are stable and nonseparable upon heating.

KW - DNA

KW - Nanotubes

KW - Nanowires

KW - Nucleic acids

KW - Self-assembly

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JO - Nano Letters

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Covalently linked DNA nanotubes

Abstract

Keywords

ASJC Scopus subject areas

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