COVID-19 Vaccination and New Onset Glomerular Disease: Results from the IRocGN2 International Registry

Meryl Waldman, Ninet Sinaii, Edgar V. Lerma, Anila Abraham Kurien, Kenar D. Jhaveri, Nupur N. Uppal, Rimda Wanchoo, Rupali Avasare, Jonathan E. Zuckerman, Adrian Liew, Alexander J. Gallan, Ashraf El-Meanawy, Yoram Yagil, Larissa Lebedev, Krishoban Baskaran, Eswari Vilayur, Adrienne Cohen, Nethmi Weerasinghe, Ioannis Petrakis, Kostas StylianouHariklia Gakiopoulou, Alexander J. Hamilton, Naomi Edney, Rachel Millner, Smaragdi Marinaki, Joshua L. Rein, John Paul Killen, Jose Manuel Rodríguez Chagolla, Claude Bassil, Ramon Lopez del Valle, Jordan Evans, Anatoly Urisman, Mona Zawaideh, Pravir V. Baxi, Roger Rodby, Mahesha Vankalakunti, Juan M. Mejia Vilet, Silvia E. Ramirez Andrade, Mal P. Homan, Enzo Vásquez Jiménez, Natasha Perinpanayagam, Juan Carlos Q. Velez, Muner M.B. Mohamed, Khalid M.G. Mohammed, Arjun Sekar, Laura Ollila, Abraham W. Aron, Kevin Javier Arellano Arteaga, Mahmud Islam, Esperanza Moral Berrio, Omar Maoujoud, Rebecca Ruf Morales, Regan Seipp, Carl E. Schulze, Robert H. Yenchek, Irina Vancea, Muhammad Muneeb, Lilian Howard, Tiffany N. Caza

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background Patients with de novo glomerular disease (GD) with various renal histologies have been reported after vaccination against SARS-CoV-2. Causality has not been established, and the long-term outcomes are not known. To better characterize the GDs and clinical courses/outcomes, we created the International Registry of COVID-19 vaccination and Glomerulonephritis to study in aggregate patients with de novo GN suspected after COVID-19 vaccine exposure. Methods A REDCap survey was used for anonymized data collection. Detailed information on vaccination type and timing and GD histology were recorded in the registry. We collected serial information on laboratory values (before and after vaccination and during follow-up), treatments, and kidney-related outcomes. Results Ninety-eight patients with GD were entered into the registry over 11 months from 44 centers throughout the world. Median follow-up was 89 days after diagnosis. IgA nephropathy (IgAN) and minimal change disease (MCD) were the most common kidney diseases reported. Recovery of kidney function and remission of proteinuria were more likely in IgAN and MCD at 4-6 months than with pauci-immune GN/vasculitis and membranous nephropathy. Conclusions The development of GD after vaccination against SARS-CoV-2 may be a very rare adverse event. Temporal association is present for IgAN and MCD, but causality is not firmly established. Kidney outcomes for IgAN and MCD are favorable. No changes in vaccination risk-benefit assessment are recommended based on these findings.

Original languageEnglish
Pages (from-to)349-362
Number of pages14
JournalKidney360
Volume4
Issue number3
DOIs
StatePublished - 1 Mar 2023

ASJC Scopus subject areas

  • Nephrology
  • Medicine (all)
  • Medicine (miscellaneous)

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