TY - CHAP
T1 - Creating Unique Cell Microenvironments for the Engineering of a Functional Cardiac Patch
AU - Dvir, Tal
AU - Leor, Jonathan
AU - Cohen, Smadar
N1 - Publisher Copyright:
© 2010, Springer-Verlag Berlin Heidelberg.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Tissue engineering is an approach used to create a functional cardiac patch for the purpose of scar support after a myocardial infarct (MI). Cardiac cells, or cells of other sources, are seeded into scaffolds, which provide an artificial biomechanical support until the cells secrete extracellular matrix and regenerate into a functional tissue. In this chapter we describe the creative design of various cell microenvironments, which promote the development of a thick vascularized cardiac patch, ready to face the harsh conditions of the infarcted heart. Among these microenvironments are unique bioreactor systems that increase mass transfer through the developing cardiac tissue at the in vitro engineering stage and the use of various vascularization techniques, including the use of the body as a bioreactor to induce rapid vascularization prior to transplantation on the infarcted heart.
AB - Tissue engineering is an approach used to create a functional cardiac patch for the purpose of scar support after a myocardial infarct (MI). Cardiac cells, or cells of other sources, are seeded into scaffolds, which provide an artificial biomechanical support until the cells secrete extracellular matrix and regenerate into a functional tissue. In this chapter we describe the creative design of various cell microenvironments, which promote the development of a thick vascularized cardiac patch, ready to face the harsh conditions of the infarcted heart. Among these microenvironments are unique bioreactor systems that increase mass transfer through the developing cardiac tissue at the in vitro engineering stage and the use of various vascularization techniques, including the use of the body as a bioreactor to induce rapid vascularization prior to transplantation on the infarcted heart.
KW - Cardiac Tissue
KW - Infarcted Heart
KW - Microvascular Network
KW - Perfusion Bioreactor
KW - Vascular Endothelial Growth Factor
UR - http://www.scopus.com/inward/record.url?scp=84940686884&partnerID=8YFLogxK
U2 - 10.1007/8415_2010_40
DO - 10.1007/8415_2010_40
M3 - Chapter
AN - SCOPUS:84940686884
T3 - Studies in Mechanobiology, Tissue Engineering and Biomaterials
SP - 81
EP - 94
BT - Studies in Mechanobiology, Tissue Engineering and Biomaterials
PB - Springer
ER -