CRISPR-Cas9 system for fungi genome engineering toward industrial applications

Lakkakula Satish, Sasanala Shamili, Balasubramanian Muthubharathi, S. Antony Ceasar, Ariel Kushmaro, Vijai Singh, Yaron Sitrit

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The discovery of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated protein 9 (Cas9) system has emerged as a prominent system for genome engineering in diverse organisms. Biotechnological and industrial production of foods, beverages, chemicals, proteins and fuels is dependent on effective production systems, commonly utilizing the genetically modified organisms. CRISPR-Cas9 approach has been used for genome editing of wide range of fungi and yeast for industrial applications. It has enabled significant advances in mycology research by hastening the growth of study models for those aiming to discover and validate novel compounds. This chapter aims to bring a comprehensive detail on application of CRISPR-Cas9 mediated genome editing in different fungi toward industrial applications.
Original languageEnglish
Title of host publicationGenome Engineering via CRISPR-Cas9 System
Pages69-81
Number of pages13
DOIs
StatePublished - 1 Jan 2020

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