Crossing the membrane in Archaea, the third domain of life

Doron Calo, Jerry Eichler

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Many of the recent advancements in the field of protein translocation, particularly from the structural perspective, have relied on Archaea. For instance, the solved structures of the translocon from the methanoarchaeon Methanocaldococcus jannaschii of the ribosomal large subunit from the haloarchaeon Haloarcula marismortui and of components of the SRP pathway from several archaeal species have provided novel insight into various aspects of the translocation event. Given the major contribution that Archaea have made to our understanding of how proteins enter and traverse membranes, it is surprising that relatively little is known of protein translocation in Archaea in comparison to the well-defined translocation pathways of Eukarya and Bacteria. What is known, however, points to archaeal translocation as comprising a mosaic of eukaryal and bacterial traits together with aspects of the process seemingly unique to this, the third domain of life. Here, current understanding of archaeal protein translocation is considered. This article is part of a Special Issue entitled Protein translocation across or insertion into membranes.

Original languageEnglish
Pages (from-to)885-891
Number of pages7
JournalBiochimica et Biophysica Acta - Biomembranes
Issue number3
StatePublished - 1 Mar 2011

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology


Dive into the research topics of 'Crossing the membrane in Archaea, the third domain of life'. Together they form a unique fingerprint.

Cite this