Cryptosporidium passes the bile acid test to survive

Ryan D. Pardy; Danielle Karo-Atar; Irah L. King

doi:10.1016/j.pt.2025.09.006

Cryptosporidium passes the bile acid test to survive

Ryan D. Pardy, Danielle Karo-Atar, Irah L. King

Department of Clinical Biochemistry and Pharmacology

Research output: Contribution to journal › Short survey › peer-review

Abstract

Cryptosporidium spp. are an important cause of diarrheal disease worldwide. However, pathogenesis can vary between and within parasite species. Huang et al. identified CpMRP1 as a transporter of the microbial metabolite deoxycholic acid and virulence factor that determines infection outcome in susceptible mice.

Original language	English
Pages (from-to)	950-951
Number of pages	2
Journal	Trends in Parasitology
Volume	41
Issue number	11
DOIs	https://doi.org/10.1016/j.pt.2025.09.006
State	Published - 1 Nov 2025

Keywords

ABC transporter
Cryptosporidium
microbial metabolites
virulence factors

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/j.pt.2025.09.006

Cite this

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title = "Cryptosporidium passes the bile acid test to survive",

abstract = "Cryptosporidium spp. are an important cause of diarrheal disease worldwide. However, pathogenesis can vary between and within parasite species. Huang et al. identified CpMRP1 as a transporter of the microbial metabolite deoxycholic acid and virulence factor that determines infection outcome in susceptible mice.",

keywords = "ABC transporter, Cryptosporidium, microbial metabolites, virulence factors",

author = "Pardy, \{Ryan D.\} and Danielle Karo-Atar and King, \{Irah L.\}",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd",

year = "2025",

month = nov,

day = "1",

doi = "10.1016/j.pt.2025.09.006",

language = "English",

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journal = "Trends in Parasitology",

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TY - JOUR

T1 - Cryptosporidium passes the bile acid test to survive

AU - Pardy, Ryan D.

AU - Karo-Atar, Danielle

AU - King, Irah L.

PY - 2025/11/1

Y1 - 2025/11/1

N2 - Cryptosporidium spp. are an important cause of diarrheal disease worldwide. However, pathogenesis can vary between and within parasite species. Huang et al. identified CpMRP1 as a transporter of the microbial metabolite deoxycholic acid and virulence factor that determines infection outcome in susceptible mice.

AB - Cryptosporidium spp. are an important cause of diarrheal disease worldwide. However, pathogenesis can vary between and within parasite species. Huang et al. identified CpMRP1 as a transporter of the microbial metabolite deoxycholic acid and virulence factor that determines infection outcome in susceptible mice.

KW - ABC transporter

KW - Cryptosporidium

KW - microbial metabolites

KW - virulence factors

UR - https://www.scopus.com/pages/publications/105017050131

U2 - 10.1016/j.pt.2025.09.006

DO - 10.1016/j.pt.2025.09.006

M3 - Short survey

C2 - 41015748

AN - SCOPUS:105017050131

SN - 1471-4922

VL - 41

SP - 950

EP - 951

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 11

ER -

Cryptosporidium passes the bile acid test to survive

Abstract

Keywords

ASJC Scopus subject areas

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