Crystal engineering with cocrystals of benzo-[18]crown-6 and urea and thiourea derivatives

Sara Wishkerman, Joel Bernstein, Magali B. Hickey

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Cocrystallization experiments were carried out to study the efficacy of Benzo-[18]crown-6 (B18C6) as a cocrystallizing agent (CA). Traditional solution cocrystallization, high-throughput cocrystallization, dry grinding and solvent-drop grinding cocrystallization have led to the discovery of five new cocrystals of B18C6 with urea, thiourea, and their derivatives. The cocrystals have been characterized by a variety of methods, including X-ray diffraction, vibrational spectroscopy (infrared), and optical microscopy (HSM). We have also examined the structures in order to determine the viability and the reproducibility of the R 2 1(6) motif between the donor hydrogen and the ether group of B18C6.

Original languageEnglish
Pages (from-to)3204-3210
Number of pages7
JournalCrystal Growth and Design
Issue number7
StatePublished - 1 Jul 2009

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics


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