Crystalline calcium carbonate and hydrogels as microenvironment for stem cells

Liliana Astachov, Zvi Nevo, Moran Aviv, Razi Vago

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Stem cell development and fate decisions are dictated by the microenvironment in which the stem cell is embedded. Among the advanced goals of tissue engineering is the creation of a microenvironment that will support the maintenance and differentiation of the stem cell - based on embryonic and adult stem cells as potent, cellular sources - for a variety of clinical applications. This review discusses some of the approaches used to create regulatory and instructive microenvironments for the directed differentiation of mesenchymal stem cells (MSCs) using three-dimensional crystalline calcium carbonate biomaterials of marine origin combined with a hydrated gel based on hyaluronan.

Original languageEnglish
Pages (from-to)458-471
Number of pages14
JournalFrontiers in Bioscience - Landmark
Issue number2
StatePublished - 1 Jan 2011


  • Aragonite
  • Calcite
  • Hyaluronan
  • Hydrogel
  • MSCs
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)
  • Immunology and Microbiology (all)


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