CSF inositol does not predict antidepressant response to inositol

J. Levine, L. Kurtzman, A. Rapoport, J. Zimmerman, Y. Bersudsky, J. Shapiro, R. H. Belmaker, G. Agam

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


CSF inositol was reported to be reduced in depression and inositol has been reported to be effective in treatment of depression. We studied CSF inositol in 18 drug-free depressed patients and 36 normal controls; the depressed patients then participated in an open trial of 18 gm daily inositol treatment for 4 weeks. There was no difference in pre-treatment CSF inositol between depressed patients and controls. CSF inositol levels did not predict response on the Hamilton Depression Scale to 4 weeks of inositol treatment.

Original languageEnglish
Pages (from-to)1457-1462
Number of pages6
JournalJournal of Neural Transmission
Issue number12
StatePublished - 1 Dec 1996


  • CSF
  • Depression
  • Inositol

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry


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