CSF inositol does not predict antidepressant response to inositol

J. Levine, L. Kurtzman, A. Rapoport, J. Zimmerman, Y. Bersudsky, J. Shapiro, R. H. Belmaker, G. Agam

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


CSF inositol was reported to be reduced in depression and inositol has been reported to be effective in treatment of depression. We studied CSF inositol in 18 drug-free depressed patients and 36 normal controls; the depressed patients then participated in an open trial of 18 gm daily inositol treatment for 4 weeks. There was no difference in pre-treatment CSF inositol between depressed patients and controls. CSF inositol levels did not predict response on the Hamilton Depression Scale to 4 weeks of inositol treatment.

Original languageEnglish
Pages (from-to)1457-1462
Number of pages6
JournalJournal of Neural Transmission
Issue number12
StatePublished - 1 Dec 1996


  • CSF
  • Depression
  • Inositol

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry


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