CSF tau correlates with the degree of cortical involvement in E200K familial Creutzfeldt-Jakob disease

Oren S. Cohen; Joab Chapman; Amos D. Korczyn; Oliver L. Siaw; Naama Warman-Alaluf; Zeev Nitsan; Shmuel Appel; Esther Kahana; Hanna Rosenmann; Chen Hoffmann

doi:10.1016/j.neulet.2016.10.012

CSF tau correlates with the degree of cortical involvement in E200K familial Creutzfeldt-Jakob disease

Oren S. Cohen, Joab Chapman, Amos D. Korczyn, Oliver L. Siaw, Naama Warman-Alaluf, Zeev Nitsan, Shmuel Appel, Esther Kahana, Hanna Rosenmann, Chen Hoffmann

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Cerebrospinal fluid (CSF) tau was found to correlate with disease severity and cognitive status in E200K familial Creutzfeldt-Jakob disease (fCJD) patients. The objective of the present study was to test whether tau levels in the CSF also correlate with the disease burden as reflected by the degree of cortical involvement in DWI MRI. Forty-four consecutive E200K fCJD patients (25 males, mean age 58.6 ± 7.5, range 48–75 years) were recruited to the study and had a CSF tau examination as well as measurements of the extent of the cortical involvement in the DWI axial MRI. Correlation was tested using Pearson test. A significant correlation (r = 0.617 p < 0.0001) was found between CSF tau levels and the extent of cortical involvement. This correlation between tau levels and the disease burden reinforce the notion that tau can be used as a biomarker reflecting the extent of disease in patients with E200K fCJD.

Original language	English
Pages (from-to)	76-78
Number of pages	3
Journal	Neuroscience Letters
Volume	634
DOIs	https://doi.org/10.1016/j.neulet.2016.10.012
State	Published - 10 Nov 2016

Keywords

Creutzfeldt-Jakob disease
Disease severity
E200K mutation
MRI
Tau protein

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.neulet.2016.10.012

Cite this

@article{709aea65e9704fda9ed5a2e3b7f1a091,

title = "CSF tau correlates with the degree of cortical involvement in E200K familial Creutzfeldt-Jakob disease",

abstract = "Cerebrospinal fluid (CSF) tau was found to correlate with disease severity and cognitive status in E200K familial Creutzfeldt-Jakob disease (fCJD) patients. The objective of the present study was to test whether tau levels in the CSF also correlate with the disease burden as reflected by the degree of cortical involvement in DWI MRI. Forty-four consecutive E200K fCJD patients (25 males, mean age 58.6 ± 7.5, range 48–75 years) were recruited to the study and had a CSF tau examination as well as measurements of the extent of the cortical involvement in the DWI axial MRI. Correlation was tested using Pearson test. A significant correlation (r = 0.617 p < 0.0001) was found between CSF tau levels and the extent of cortical involvement. This correlation between tau levels and the disease burden reinforce the notion that tau can be used as a biomarker reflecting the extent of disease in patients with E200K fCJD.",

keywords = "Creutzfeldt-Jakob disease, Disease severity, E200K mutation, MRI, Tau protein",

author = "Cohen, {Oren S.} and Joab Chapman and Korczyn, {Amos D.} and Siaw, {Oliver L.} and Naama Warman-Alaluf and Zeev Nitsan and Shmuel Appel and Esther Kahana and Hanna Rosenmann and Chen Hoffmann",

note = "Publisher Copyright: {\textcopyright} 2016",

year = "2016",

month = nov,

day = "10",

doi = "10.1016/j.neulet.2016.10.012",

language = "English",

volume = "634",

pages = "76--78",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - CSF tau correlates with the degree of cortical involvement in E200K familial Creutzfeldt-Jakob disease

AU - Cohen, Oren S.

AU - Chapman, Joab

AU - Korczyn, Amos D.

AU - Siaw, Oliver L.

AU - Warman-Alaluf, Naama

AU - Nitsan, Zeev

AU - Appel, Shmuel

AU - Kahana, Esther

AU - Rosenmann, Hanna

AU - Hoffmann, Chen

PY - 2016/11/10

Y1 - 2016/11/10

N2 - Cerebrospinal fluid (CSF) tau was found to correlate with disease severity and cognitive status in E200K familial Creutzfeldt-Jakob disease (fCJD) patients. The objective of the present study was to test whether tau levels in the CSF also correlate with the disease burden as reflected by the degree of cortical involvement in DWI MRI. Forty-four consecutive E200K fCJD patients (25 males, mean age 58.6 ± 7.5, range 48–75 years) were recruited to the study and had a CSF tau examination as well as measurements of the extent of the cortical involvement in the DWI axial MRI. Correlation was tested using Pearson test. A significant correlation (r = 0.617 p < 0.0001) was found between CSF tau levels and the extent of cortical involvement. This correlation between tau levels and the disease burden reinforce the notion that tau can be used as a biomarker reflecting the extent of disease in patients with E200K fCJD.

AB - Cerebrospinal fluid (CSF) tau was found to correlate with disease severity and cognitive status in E200K familial Creutzfeldt-Jakob disease (fCJD) patients. The objective of the present study was to test whether tau levels in the CSF also correlate with the disease burden as reflected by the degree of cortical involvement in DWI MRI. Forty-four consecutive E200K fCJD patients (25 males, mean age 58.6 ± 7.5, range 48–75 years) were recruited to the study and had a CSF tau examination as well as measurements of the extent of the cortical involvement in the DWI axial MRI. Correlation was tested using Pearson test. A significant correlation (r = 0.617 p < 0.0001) was found between CSF tau levels and the extent of cortical involvement. This correlation between tau levels and the disease burden reinforce the notion that tau can be used as a biomarker reflecting the extent of disease in patients with E200K fCJD.

KW - Creutzfeldt-Jakob disease

KW - Disease severity

KW - E200K mutation

KW - MRI

KW - Tau protein

UR - http://www.scopus.com/inward/record.url?scp=84991444239&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2016.10.012

DO - 10.1016/j.neulet.2016.10.012

M3 - Article

C2 - 27721036

AN - SCOPUS:84991444239

SN - 0304-3940

VL - 634

SP - 76

EP - 78

JO - Neuroscience Letters

JF - Neuroscience Letters

ER -

CSF tau correlates with the degree of cortical involvement in E200K familial Creutzfeldt-Jakob disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this