CT findings in neonatal hypothermia

Hanna Schulman, Lia Laufer, Julia Berginer, Eli Hershkowitz, Tamar Berenstein, Shaul Sofer, Esther Maor, Yancu Hertzanu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background. Newborn infants are particularly prone to hypothermia, a condition with a high mortality. Objective. To study the CT brain patterns in infants with hypothermia and neurological symptoms. Materials and methods. We reviewed the brain CT of nine infants with neonatal hypothermia, multiple organ failure, seizures and coma. Results. Two infants had normal CT scans, acutely and at follow-up, and were clinically normal at follow-up. In seven infants, CT showed diffuse cerebral oedema, with reversal of the normal density relationship between grey and white matter and a relative increased density of the thalami, brainstem and cerebellum the 'reversal sign'. In six surviving infants with severe developmental delay, follow-up CT revealed cerebral atrophy with multicystic encephalomalacia. Conclusions. The 'reversal sign' has been described in the abused child, birth asphyxia and anoxia due to drowning. Neonatal hypothermia is offered as a further cause.

Original languageEnglish
Pages (from-to)414-417
Number of pages4
JournalPediatric Radiology
Issue number6
StatePublished - 1 Jun 1998

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging


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