Cumulative clinical pregnancy rates after COH and IUI in subfertile couples

Jacob Farhi, Raoul Orvieto

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


To evaluate the influence of female age and cause of infertility on the outcome of controlled ovarian hyperstimulation (COH) and intrauterine insemination (IUI), we studied 2717 COH cycles in 1035 subfertile couples. The cumulative clinical pregnancy rates were 39 and 58 after three and six COH cycles, respectively. The cumulative pregnancy rate significantly decreased with maternal age and differed by cause of infertility. The cumulative pregnancy rate continued to increase with an increase in COH cycle number up to the third, or forth cycle, in patients with mechanical and combined infertility, respectively, and in up to the second cycle in patients aged 40 years or more. These findings provide treatment guidelines for clinicians in determining the likelihood of treatment success and the point at which to proceed to the next treatment strategy.

Original languageEnglish
Pages (from-to)500-504
Number of pages5
JournalGynecological Endocrinology
Issue number7
StatePublished - 1 Jul 2010


  • Age
  • Coh
  • Cumulative pregnancy rate
  • Infertility
  • Iui

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Obstetrics and Gynecology


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