Cu(OAc)2 catalyzed ultrasound assisted rapid synthesis of isocoumarin derivatives bearing 3-oxobutyl moiety at C-4 position

Sidda Ramarao, Mohanreddy Pothireddy, Rapolu Venkateshwarlu, Krishna Murthy VR Moturu, Vidavalur Siddaiah, Rambabu Dandela, Manojit Pal

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A rapid synthesis of isocoumarins has been achieved via the Cu-catalysed cascade reaction involving tandem intramolecular cyclization followed by olefin addition under ultrasound irradiation. The methodology involved one-pot reaction of 2-alkynylbenzoate esters with methyl vinyl ketone in the presence of Cu(OAc)2 in aqueous DMF to afford a range of isocoumarin derivatives bearing 3-oxobutyl moiety at C-4 position. The use of inexpensive, stable and environmentally friendly catalyst along with aqueous media, shorter reaction time and simple operational procedure are the key advantages of this Pd-free methodology. 2009 Elsevier Ltd. All rights reserved.

Original languageEnglish
Article number132418
JournalJournal of Molecular Structure
Volume1254
DOIs
StatePublished - 15 Apr 2022
Externally publishedYes

Keywords

  • Cu(OAc)
  • Cyclization
  • Ultrasound
  • Ísocoumarin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry

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