Curcumin-docetaxel co-loaded nanosuspension for enhanced anti-breast cancer activity

Bhanu P. Sahu, Hemanga Hazarika, Rituraj Bharadwaj, Pojul Loying, Rinku Baishya, Suvakanta Dash, Malay K. Das

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

A curcumin-docetaxel co-loaded nanosuspension with increased anti-breast cancer activity was developed. Curcumin is a potential anticancer agent with p-glycoprotein (p-gp) inhibiting activity may be co-administered with docetaxel as a nanosuspension to enhance its anticancer effect by increasing the oral bioavailability and decreasing drug efflux. Methods: Nanosuspensions of curcumin and docetaxel were prepared by precipitation-homozenisation technique and evaluated for particle size, polydispersity, zeta potential and drug release. The in vitro MTT assay was conducted using MCF-7 for anti-breast cancer activity. The in vivo biodistribution by radiolabeling and tumor inhibition study was conducted in mice. Results: Homogenous nanosuspensions of 80 ± 20 nm were obtained with increased solubility. The drugs as nanosuspensions showed higher cytotoxicity on MCF-7 cell line compared to their suspensions due to the increased in vitro cellular uptake. Due to this increased solubility, sensitization of tumor cells and inhibition of p-gp the in-vivo results showed greater tumor inhibition rate of up to 70% in MCF-7 treated mice. Histopathological results showed higher apoptotic activity and reduced level of angiogenesis. Conclusions: The in vitro and in vivo study of the nanosuspensions has shown that Co-administration of Curcumin as a p-gp inhibitor with docetaxel may have the potential to increase the anti-breast cancer efficacy of both drugs.

Original languageEnglish
Pages (from-to)1065-1074
Number of pages10
JournalExpert Opinion on Drug Delivery
Volume13
Issue number8
DOIs
StatePublished - 2 Aug 2016
Externally publishedYes

Keywords

  • Curcumin
  • MCF-7
  • biodistribution
  • breast cancer
  • docetaxel
  • nanaosuspension
  • radiolabeling

ASJC Scopus subject areas

  • Pharmaceutical Science

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