Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α

Maya Mouler Rechtman; Ofir Har-Noy; Iddo Bar-Yishay; Sigal Fishman; Yaarit Adamovich; Yosef Shaul; Zamir Halpern; Amir Shlomai

doi:10.1016/j.febslet.2010.04.067

Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α

Maya Mouler Rechtman
, Ofir Har-Noy
, Iddo Bar-Yishay
, Sigal Fishman
, Yaarit Adamovich
, Yosef Shaul
, Zamir Halpern
, Amir Shlomai

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication. This inhibition is mediated via down-regulation of PGC-1α, a starvation-induced protein that initiates the gluconeogenesis cascade and that has been shown to robustly coactivate HBV transcription. We suggest curcumin as a host targeted therapy for HBV infection that may complement current virus-specific therapies.

Original language	English
Pages (from-to)	2485-2490
Number of pages	6
Journal	FEBS Letters
Volume	584
Issue number	11
DOIs	https://doi.org/10.1016/j.febslet.2010.04.067
State	Published - 1 Jun 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-viral therapy
Hepatitis B virus
Metabolovirus
Nutrition

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/j.febslet.2010.04.067

Cite this

@article{fa8124c837b045a8a08179bf8384f7aa,

title = "Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α",

abstract = "Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication. This inhibition is mediated via down-regulation of PGC-1α, a starvation-induced protein that initiates the gluconeogenesis cascade and that has been shown to robustly coactivate HBV transcription. We suggest curcumin as a host targeted therapy for HBV infection that may complement current virus-specific therapies.",

keywords = "Anti-viral therapy, Hepatitis B virus, Metabolovirus, Nutrition",

author = "\{Mouler Rechtman\}, Maya and Ofir Har-Noy and Iddo Bar-Yishay and Sigal Fishman and Yaarit Adamovich and Yosef Shaul and Zamir Halpern and Amir Shlomai",

year = "2010",

month = jun,

day = "1",

doi = "10.1016/j.febslet.2010.04.067",

language = "English",

volume = "584",

pages = "2485--2490",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley and Sons Inc.",

number = "11",

}

TY - JOUR

T1 - Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α

AU - Mouler Rechtman, Maya

AU - Har-Noy, Ofir

AU - Bar-Yishay, Iddo

AU - Fishman, Sigal

AU - Adamovich, Yaarit

AU - Shaul, Yosef

AU - Halpern, Zamir

AU - Shlomai, Amir

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication. This inhibition is mediated via down-regulation of PGC-1α, a starvation-induced protein that initiates the gluconeogenesis cascade and that has been shown to robustly coactivate HBV transcription. We suggest curcumin as a host targeted therapy for HBV infection that may complement current virus-specific therapies.

AB - Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication. This inhibition is mediated via down-regulation of PGC-1α, a starvation-induced protein that initiates the gluconeogenesis cascade and that has been shown to robustly coactivate HBV transcription. We suggest curcumin as a host targeted therapy for HBV infection that may complement current virus-specific therapies.

KW - Anti-viral therapy

KW - Hepatitis B virus

KW - Metabolovirus

KW - Nutrition

UR - https://www.scopus.com/pages/publications/77952956370

U2 - 10.1016/j.febslet.2010.04.067

DO - 10.1016/j.febslet.2010.04.067

M3 - Article

C2 - 20434445

AN - SCOPUS:77952956370

SN - 0014-5793

VL - 584

SP - 2485

EP - 2490

JO - FEBS Letters

JF - FEBS Letters

IS - 11

ER -

Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this