Current approaches, challenges and future directions for monitoring treatment response in prostate cancer

T. J. Wallace, T. Torre, M. Grob, J. Yu, I. Avital, B. L.D.M. Brücher, A. Stojadinovic, Y. G. Man

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations

Abstract

Prostate cancer is the most commonly diagnosed non-cutaneous neoplasm in men in the United States and the second leading cause of cancer mortality. One in 7 men will be diagnosed with prostate cancer during their lifetime. As a result, monitoring treatment response is of vital importance. The cornerstone of current approaches in monitoring treatment response remains the prostate-specific antigen (PSA). However, with the limitations of PSA come challenges in our ability to monitor treatment success. Defining PSA response is different depending on the individual treatment rendered potentially making it difficult for those not trained in urologic oncology to understand. Furthermore, standard treatment response criteria do not apply to prostate cancer further complicating the issue of treatment response. Historically, prostate cancer has been difficult to image and no single modality has been consistently relied upon to measure treatment response. However, with newer imaging modalities and advances in our understanding and utilization of specific biomarkers, the future for monitoring treatment response in prostate cancer looks bright.

Original languageEnglish
Pages (from-to)3-24
Number of pages22
JournalJournal of Cancer
Volume5
Issue number1
DOIs
StatePublished - 14 Feb 2014
Externally publishedYes

Keywords

  • Monitoring treatment response
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology

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