Current treatment options for acute skin and skin-structure infections

Yoav Golan

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Acute bacterial skin and skin-structure infections (ABSSSIs) are a common reason for seeking care at acute healthcare facilities, including emergency departments. Staphylococcus aureus is the most common organism associated with these infections, and the emergence of community-associated methicillin-resistant Staphylococcus aureus (MRSA) has represented a considerable challenge in their treatment. To address this need, a number of new antibiotics have been developed for the treatment of ABSSSIs in the past several years. Most of these agents focus primarily on gram-positive organisms, particularly MRSA; however, there has not been an oral agent that can reliably treat MRSA, as well as relevant gram-negative pathogens. Acute skin infections that involve mixed gram-positive and gram-negative pathogens must also be considered as they can be associated with discordant antimicrobial therapy. Here, I review ABSSSI treatment guidelines in the hospital setting and discuss current and future antibiotic options for treatment of this commonly encountered infection.

Original languageEnglish
Pages (from-to)S206-S212
JournalClinical Infectious Diseases
StatePublished - 8 Apr 2019
Externally publishedYes


  • abscess
  • antibiotic resistance
  • skin infection
  • therapy

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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