CXCL10 and IL-6: Markers of two different forms of intra-amniotic inflammation in preterm labor

Roberto Romero; Piya Chaemsaithong; Noppadol Chaiyasit; Nikolina Docheva; Zhong Dong; Chong Jai Kim; Yeon Mee Kim; Jung Sun Kim; Faisal Qureshi; Suzanne M. Jacques; Bo Hyun Yoon; Tinnakorn Chaiworapongsa; Lami Yeo; Sonia S. Hassan; Offer Erez; Steven J. Korzeniewski

doi:10.1111/aji.12685

CXCL10 and IL-6: Markers of two different forms of intra-amniotic inflammation in preterm labor

Roberto Romero, Piya Chaemsaithong, Noppadol Chaiyasit, Nikolina Docheva, Zhong Dong, Chong Jai Kim, Yeon Mee Kim, Jung Sun Kim, Faisal Qureshi, Suzanne M. Jacques, Bo Hyun Yoon, Tinnakorn Chaiworapongsa, Lami Yeo, Sonia S. Hassan, Offer Erez, Steven J. Korzeniewski

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Problem: To determine whether amniotic fluid (AF) CXCL10 concentration is associated with histologic chronic chorioamnionitis in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PROM). Method of Study: This study included 168 women who had an episode of PTL or preterm PROM. AF interleukin (IL)-6 and CXCL10 concentrations were determined by immunoassay. Results: (i) Increased AF CXCL10 concentration was associated with chronic (OR: 4.8; 95% CI: 1.7-14), but not acute chorioamnionitis; (ii) increased AF IL-6 concentration was associated with acute (OR: 4.2; 95% CI: 1.3-13.7) but not chronic chorioamnionitis; and (iii) an increase in AF CXCL10 concentration was associated with placental lesions consistent with maternal anti-fetal rejection (OR: 3.7; 95% CI: 1.3-10.4). (iv) All patients with elevated AF CXCL10 and IL-6 delivered preterm. Conclusion: Increased AF CXCL10 concentration is associated with chronic chorioamnionitis or maternal anti-fetal rejection, whereas increased AF IL-6 concentration is associated with acute histologic chorioamnionitis.

Original language	English
Article number	e12685
Journal	American Journal of Reproductive Immunology
Volume	78
Issue number	1
DOIs	https://doi.org/10.1111/aji.12685
State	Published - 1 Jul 2017
Externally published	Yes

Keywords

allograft
amniocentesis
biomarker
chorioamnionitis
chronic inflammation
cytokine
maternal anti-fetal rejection

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

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10.1111/aji.12685

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Romero, R., Chaemsaithong, P., Chaiyasit, N., Docheva, N., Dong, Z., Kim, C. J., Kim, Y. M., Kim, J. S., Qureshi, F., Jacques, S. M., Yoon, B. H., Chaiworapongsa, T., Yeo, L., Hassan, S. S., Erez, O., & Korzeniewski, S. J. (2017). CXCL10 and IL-6: Markers of two different forms of intra-amniotic inflammation in preterm labor. American Journal of Reproductive Immunology, 78(1), Article e12685. https://doi.org/10.1111/aji.12685

@article{d371d83c564944eb94d4576007e79389,

title = "CXCL10 and IL-6: Markers of two different forms of intra-amniotic inflammation in preterm labor",

abstract = "Problem: To determine whether amniotic fluid (AF) CXCL10 concentration is associated with histologic chronic chorioamnionitis in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PROM). Method of Study: This study included 168 women who had an episode of PTL or preterm PROM. AF interleukin (IL)-6 and CXCL10 concentrations were determined by immunoassay. Results: (i) Increased AF CXCL10 concentration was associated with chronic (OR: 4.8; 95% CI: 1.7-14), but not acute chorioamnionitis; (ii) increased AF IL-6 concentration was associated with acute (OR: 4.2; 95% CI: 1.3-13.7) but not chronic chorioamnionitis; and (iii) an increase in AF CXCL10 concentration was associated with placental lesions consistent with maternal anti-fetal rejection (OR: 3.7; 95% CI: 1.3-10.4). (iv) All patients with elevated AF CXCL10 and IL-6 delivered preterm. Conclusion: Increased AF CXCL10 concentration is associated with chronic chorioamnionitis or maternal anti-fetal rejection, whereas increased AF IL-6 concentration is associated with acute histologic chorioamnionitis.",

keywords = "allograft, amniocentesis, biomarker, chorioamnionitis, chronic inflammation, cytokine, maternal anti-fetal rejection",

author = "Roberto Romero and Piya Chaemsaithong and Noppadol Chaiyasit and Nikolina Docheva and Zhong Dong and Kim, {Chong Jai} and Kim, {Yeon Mee} and Kim, {Jung Sun} and Faisal Qureshi and Jacques, {Suzanne M.} and Yoon, {Bo Hyun} and Tinnakorn Chaiworapongsa and Lami Yeo and Hassan, {Sonia S.} and Offer Erez and Korzeniewski, {Steven J.}",

note = "Publisher Copyright: Published 2017. This article is a U.S. Government work and is in the public domain in the USA. American Journal of Reproductive Immunology published by John Wiley & Sons Ltd.",

year = "2017",

month = jul,

day = "1",

doi = "10.1111/aji.12685",

language = "English",

volume = "78",

journal = "American Journal of Reproductive Immunology",

issn = "1046-7408",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "1",

}

Romero, R, Chaemsaithong, P, Chaiyasit, N, Docheva, N, Dong, Z, Kim, CJ, Kim, YM, Kim, JS, Qureshi, F, Jacques, SM, Yoon, BH, Chaiworapongsa, T, Yeo, L, Hassan, SS, Erez, O & Korzeniewski, SJ 2017, 'CXCL10 and IL-6: Markers of two different forms of intra-amniotic inflammation in preterm labor', American Journal of Reproductive Immunology, vol. 78, no. 1, e12685. https://doi.org/10.1111/aji.12685

TY - JOUR

T1 - CXCL10 and IL-6

T2 - Markers of two different forms of intra-amniotic inflammation in preterm labor

AU - Romero, Roberto

AU - Chaemsaithong, Piya

AU - Chaiyasit, Noppadol

AU - Docheva, Nikolina

AU - Dong, Zhong

AU - Kim, Chong Jai

AU - Kim, Yeon Mee

AU - Kim, Jung Sun

AU - Qureshi, Faisal

AU - Jacques, Suzanne M.

AU - Yoon, Bo Hyun

AU - Chaiworapongsa, Tinnakorn

AU - Yeo, Lami

AU - Hassan, Sonia S.

AU - Erez, Offer

AU - Korzeniewski, Steven J.

N1 - Publisher Copyright: Published 2017. This article is a U.S. Government work and is in the public domain in the USA. American Journal of Reproductive Immunology published by John Wiley & Sons Ltd.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Problem: To determine whether amniotic fluid (AF) CXCL10 concentration is associated with histologic chronic chorioamnionitis in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PROM). Method of Study: This study included 168 women who had an episode of PTL or preterm PROM. AF interleukin (IL)-6 and CXCL10 concentrations were determined by immunoassay. Results: (i) Increased AF CXCL10 concentration was associated with chronic (OR: 4.8; 95% CI: 1.7-14), but not acute chorioamnionitis; (ii) increased AF IL-6 concentration was associated with acute (OR: 4.2; 95% CI: 1.3-13.7) but not chronic chorioamnionitis; and (iii) an increase in AF CXCL10 concentration was associated with placental lesions consistent with maternal anti-fetal rejection (OR: 3.7; 95% CI: 1.3-10.4). (iv) All patients with elevated AF CXCL10 and IL-6 delivered preterm. Conclusion: Increased AF CXCL10 concentration is associated with chronic chorioamnionitis or maternal anti-fetal rejection, whereas increased AF IL-6 concentration is associated with acute histologic chorioamnionitis.

AB - Problem: To determine whether amniotic fluid (AF) CXCL10 concentration is associated with histologic chronic chorioamnionitis in patients with preterm labor (PTL) and preterm prelabor rupture of the membranes (PROM). Method of Study: This study included 168 women who had an episode of PTL or preterm PROM. AF interleukin (IL)-6 and CXCL10 concentrations were determined by immunoassay. Results: (i) Increased AF CXCL10 concentration was associated with chronic (OR: 4.8; 95% CI: 1.7-14), but not acute chorioamnionitis; (ii) increased AF IL-6 concentration was associated with acute (OR: 4.2; 95% CI: 1.3-13.7) but not chronic chorioamnionitis; and (iii) an increase in AF CXCL10 concentration was associated with placental lesions consistent with maternal anti-fetal rejection (OR: 3.7; 95% CI: 1.3-10.4). (iv) All patients with elevated AF CXCL10 and IL-6 delivered preterm. Conclusion: Increased AF CXCL10 concentration is associated with chronic chorioamnionitis or maternal anti-fetal rejection, whereas increased AF IL-6 concentration is associated with acute histologic chorioamnionitis.

KW - allograft

KW - amniocentesis

KW - biomarker

KW - chorioamnionitis

KW - chronic inflammation

KW - cytokine

KW - maternal anti-fetal rejection

UR - http://www.scopus.com/inward/record.url?scp=85019576616&partnerID=8YFLogxK

U2 - 10.1111/aji.12685

DO - 10.1111/aji.12685

M3 - Article

AN - SCOPUS:85019576616

SN - 1046-7408

VL - 78

JO - American Journal of Reproductive Immunology

JF - American Journal of Reproductive Immunology

IS - 1

M1 - e12685

ER -

CXCL10 and IL-6: Markers of two different forms of intra-amniotic inflammation in preterm labor

Abstract

Keywords

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