Cyclic AMP and GMP in the cerebrospinal fluid after high-dose haloperidol treatment

R. H. Belmaker; J. Zohar; R. Rimon; I. Averbuch

Cyclic AMP and GMP in the cerebrospinal fluid after high-dose haloperidol treatment

R. H. Belmaker, J. Zohar, R. Rimon, I. Averbuch

Research output: Contribution to journal › Article › peer-review

Abstract

Very high dose haloperidol treatment failed to reduce cyclic AMP in cerebrospinal fluid of schizophrenic patients, whereas phenothiazines have been reported to do so. This may represent in vivo evidence for the distinction between neuroleptics that block D₁ receptors (adenylate cyclase linked) and neuroleptics that do not.

Original language	English
Pages (from-to)	217-220
Number of pages	4
Journal	Polish Journal of Pharmacology and Pharmacy
Volume	36
Issue number	2-3
State	Published - 1 Jan 1984
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Cite this

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title = "Cyclic AMP and GMP in the cerebrospinal fluid after high-dose haloperidol treatment",

abstract = "Very high dose haloperidol treatment failed to reduce cyclic AMP in cerebrospinal fluid of schizophrenic patients, whereas phenothiazines have been reported to do so. This may represent in vivo evidence for the distinction between neuroleptics that block D1 receptors (adenylate cyclase linked) and neuroleptics that do not.",

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AU - Belmaker, R. H.

AU - Zohar, J.

AU - Rimon, R.

AU - Averbuch, I.

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N2 - Very high dose haloperidol treatment failed to reduce cyclic AMP in cerebrospinal fluid of schizophrenic patients, whereas phenothiazines have been reported to do so. This may represent in vivo evidence for the distinction between neuroleptics that block D1 receptors (adenylate cyclase linked) and neuroleptics that do not.

AB - Very high dose haloperidol treatment failed to reduce cyclic AMP in cerebrospinal fluid of schizophrenic patients, whereas phenothiazines have been reported to do so. This may represent in vivo evidence for the distinction between neuroleptics that block D1 receptors (adenylate cyclase linked) and neuroleptics that do not.

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M3 - Article

AN - SCOPUS:0021272404

SN - 0301-0244

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JO - Polish Journal of Pharmacology and Pharmacy

JF - Polish Journal of Pharmacology and Pharmacy

IS - 2-3

ER -

Cyclic AMP and GMP in the cerebrospinal fluid after high-dose haloperidol treatment

Abstract

ASJC Scopus subject areas

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