Cyclic AMP reduction of frequency following ability in peripheral axons

Tina L. Seelig; Yoram Grossman; Joan J. Kendig

doi:10.1016/0006-8993(83)90198-1

Cyclic AMP reduction of frequency following ability in peripheral axons

Tina L. Seelig, Yoram Grossman, Joan J. Kendig

Physiology and Cell Biology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Radioimmunoassays for cAMP demonstrated that a β-adrenergic agonist, isoproterenol, increased cAMP levels in isolated frog sciatic nerve. Dibutyryl cAMP (db-cAMP) and isoproterenol reduced the amplitude of the compound action potential and decreased the ability of the Xenopus sciatic nerve to follow high frequency stimulation. Similar effects of db-cAMP and a phosphodiesterase inhibitor were seen on intracellularly recorded action potentials of single lobster peripheral axons. These results suggest that cAMP can modulate the electrophysiological response properties of both myelinated and unmyelinated axons.

Original language	English
Pages (from-to)	303-307
Number of pages	5
Journal	Brain Research
Volume	279
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(83)90198-1
State	Published - 21 Nov 1983

Keywords

action potential
axons
cAMP
catecholamines
frequency-following ability
β-receptors

ASJC Scopus subject areas

Neuroscience (all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(83)90198-1

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title = "Cyclic AMP reduction of frequency following ability in peripheral axons",

abstract = "Radioimmunoassays for cAMP demonstrated that a β-adrenergic agonist, isoproterenol, increased cAMP levels in isolated frog sciatic nerve. Dibutyryl cAMP (db-cAMP) and isoproterenol reduced the amplitude of the compound action potential and decreased the ability of the Xenopus sciatic nerve to follow high frequency stimulation. Similar effects of db-cAMP and a phosphodiesterase inhibitor were seen on intracellularly recorded action potentials of single lobster peripheral axons. These results suggest that cAMP can modulate the electrophysiological response properties of both myelinated and unmyelinated axons.",

keywords = "action potential, axons, cAMP, catecholamines, frequency-following ability, β-receptors",

author = "Seelig, {Tina L.} and Yoram Grossman and Kendig, {Joan J.}",

note = "Funding Information: We thank Jolanda Schreurs for suggestions and assistance with the cAMP radioimmunoassay, and Dr. Howard Schulman, Dr. Jeffrey Kocsis and Dr. Barry Connors for helpful comments on the manuscript. This work was presented in part in Soc. Neurosci. Abstr. 8 (1982) 253. Supported by NIH Grant GM22113.",

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doi = "10.1016/0006-8993(83)90198-1",

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T1 - Cyclic AMP reduction of frequency following ability in peripheral axons

AU - Seelig, Tina L.

AU - Grossman, Yoram

AU - Kendig, Joan J.

N1 - Funding Information: We thank Jolanda Schreurs for suggestions and assistance with the cAMP radioimmunoassay, and Dr. Howard Schulman, Dr. Jeffrey Kocsis and Dr. Barry Connors for helpful comments on the manuscript. This work was presented in part in Soc. Neurosci. Abstr. 8 (1982) 253. Supported by NIH Grant GM22113.

PY - 1983/11/21

Y1 - 1983/11/21

N2 - Radioimmunoassays for cAMP demonstrated that a β-adrenergic agonist, isoproterenol, increased cAMP levels in isolated frog sciatic nerve. Dibutyryl cAMP (db-cAMP) and isoproterenol reduced the amplitude of the compound action potential and decreased the ability of the Xenopus sciatic nerve to follow high frequency stimulation. Similar effects of db-cAMP and a phosphodiesterase inhibitor were seen on intracellularly recorded action potentials of single lobster peripheral axons. These results suggest that cAMP can modulate the electrophysiological response properties of both myelinated and unmyelinated axons.

AB - Radioimmunoassays for cAMP demonstrated that a β-adrenergic agonist, isoproterenol, increased cAMP levels in isolated frog sciatic nerve. Dibutyryl cAMP (db-cAMP) and isoproterenol reduced the amplitude of the compound action potential and decreased the ability of the Xenopus sciatic nerve to follow high frequency stimulation. Similar effects of db-cAMP and a phosphodiesterase inhibitor were seen on intracellularly recorded action potentials of single lobster peripheral axons. These results suggest that cAMP can modulate the electrophysiological response properties of both myelinated and unmyelinated axons.

KW - action potential

KW - axons

KW - cAMP

KW - catecholamines

KW - frequency-following ability

KW - β-receptors

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Cyclic AMP reduction of frequency following ability in peripheral axons

Abstract

Keywords

ASJC Scopus subject areas

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