Cyclic AMP reduction of frequency following ability in peripheral axons

Tina L. Seelig, Yoram Grossman, Joan J. Kendig

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Radioimmunoassays for cAMP demonstrated that a β-adrenergic agonist, isoproterenol, increased cAMP levels in isolated frog sciatic nerve. Dibutyryl cAMP (db-cAMP) and isoproterenol reduced the amplitude of the compound action potential and decreased the ability of the Xenopus sciatic nerve to follow high frequency stimulation. Similar effects of db-cAMP and a phosphodiesterase inhibitor were seen on intracellularly recorded action potentials of single lobster peripheral axons. These results suggest that cAMP can modulate the electrophysiological response properties of both myelinated and unmyelinated axons.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalBrain Research
Issue number1-2
StatePublished - 21 Nov 1983


  • action potential
  • axons
  • cAMP
  • catecholamines
  • frequency-following ability
  • β-receptors

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


Dive into the research topics of 'Cyclic AMP reduction of frequency following ability in peripheral axons'. Together they form a unique fingerprint.

Cite this