Cyclic GMP stimulates lymphocyte nucleic acid synthesis

Y. Weinstein, D. A. Chambers, H. R. Bourne, K. L. Melmon

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59 Scopus citations


AGENTS that trigger proliferation of lymphocytes1 and other cultured cells2 have also been reported to stimulate increases in intracellular guanosine 3′,5′-monophosphate (cyclic GMP). These observations raise the interesting possibility that endogenous cyclic GMP acts as the intracellular mediator of some of the effects of mitogenic agents: if so, then it might be possible to demonstrate experimentally that cyclic GMP, introduced exogenously, has a mitogenic effect. We tested this possibility in mouse splenic lymphocytes and compared the mitogenic effects of cyclic GMP and two of its synthetic derivatives, 8-bromo-cyclic GMP (8-Br cyclic GMP) and N2 O2-dibutyryl-cyclic GMP (dibutyryl cyclic GMP), with that of concanavalin A (con A), a mitogenic lectin reported1 to increase the cyclic GMP content of human lymphocytes. Our results indicate that, like con A, cyclic GMP and its derivatives can stimulate RNA and DNA synthesis in lymphocytes.

Original languageEnglish
Pages (from-to)352-353
Number of pages2
Issue number5473
StatePublished - 1 Dec 1974
Externally publishedYes

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