Cytogenetic analysis of three variants of clival chordoma

Ziv Gil, Dan M. Fliss, Nadia Voskoboinik, Leonor Leider-Trejo, Sergey Spektor, Yuval Yaron, Avi Orr-Urtreger

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Chordoma is an uncommon malignant neoplasm derived from remnants of the embryonal notochord. The tumor arises in the sacrococcygeal region in most cases. Cytogenetic information on clival chordomas is scarce due to the low incidence of these tumors. In this study, we applied the G-banding and spectral karyotyping techniques to compare the karyotypes of three variants of clival chordoma: conventional, chondroid, and dedifferentiated. We describe a normal karyotype of a chondroid chordoma and a complex karyotype of a conventional chordoma involving chromosomes 1, 2, 3, 5, 8, 9, 11, 15, 19, 20, and X. The cytogenetic analysis of the dedifferentiated chordoma showed a polyploid complex karyotype of 71-123 chromosomes with double minutes that originated from chromosome 17.

Original languageEnglish
Pages (from-to)124-130
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume154
Issue number2
DOIs
StatePublished - 15 Oct 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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