Cytokine levels in various intravenous immunoglobulin (IVIg) preparations

Yaniv Sherer; Ruihua Wu; Ilan Krause; Alexander Gorstein; Yair Levy; James B. Peter; Yehuda Shoenfeld

doi:10.3233/hab-2001-10201

Cytokine levels in various intravenous immunoglobulin (IVIg) preparations

Yaniv Sherer, Ruihua Wu, Ilan Krause, Alexander Gorstein, Yair Levy, James B. Peter, Yehuda Shoenfeld

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The mechanisms of action of intravenous immunoglobulin (IVIg) in autoimmune diseases include modulation of cytokine levels. levels. examined therefore whether direct infusion of abnormally high levels of 13 different cytokines or cytokine-inhibitors within 5 different IVIg preparations have any role in modulation of their levels. None of the measured cytokines in any of the IVIg preparations tested were above the normal levels, and regarding some no traces could be detected. Hence, modulation of cytokine levels following IVIg therapy involves other mechanisms such as interference with their secretion or cytokine-specific blocking antibodies, rather than direct infusion of cytokines.

Original language	English
Pages (from-to)	51-53
Number of pages	3
Journal	Human Antibodies
Volume	10
Issue number	2
DOIs	https://doi.org/10.3233/hab-2001-10201
State	Published - 1 Jan 2001
Externally published	Yes

Keywords

Autoantibody
Autoimmunity
Cytokine
Interleukin
Intravenous immunoglobulin

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3233/hab-2001-10201

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title = "Cytokine levels in various intravenous immunoglobulin (IVIg) preparations",

abstract = "The mechanisms of action of intravenous immunoglobulin (IVIg) in autoimmune diseases include modulation of cytokine levels. levels. examined therefore whether direct infusion of abnormally high levels of 13 different cytokines or cytokine-inhibitors within 5 different IVIg preparations have any role in modulation of their levels. None of the measured cytokines in any of the IVIg preparations tested were above the normal levels, and regarding some no traces could be detected. Hence, modulation of cytokine levels following IVIg therapy involves other mechanisms such as interference with their secretion or cytokine-specific blocking antibodies, rather than direct infusion of cytokines.",

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author = "Yaniv Sherer and Ruihua Wu and Ilan Krause and Alexander Gorstein and Yair Levy and Peter, {James B.} and Yehuda Shoenfeld",

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AU - Sherer, Yaniv

AU - Wu, Ruihua

AU - Krause, Ilan

AU - Gorstein, Alexander

AU - Levy, Yair

AU - Peter, James B.

AU - Shoenfeld, Yehuda

PY - 2001/1/1

Y1 - 2001/1/1

N2 - The mechanisms of action of intravenous immunoglobulin (IVIg) in autoimmune diseases include modulation of cytokine levels. levels. examined therefore whether direct infusion of abnormally high levels of 13 different cytokines or cytokine-inhibitors within 5 different IVIg preparations have any role in modulation of their levels. None of the measured cytokines in any of the IVIg preparations tested were above the normal levels, and regarding some no traces could be detected. Hence, modulation of cytokine levels following IVIg therapy involves other mechanisms such as interference with their secretion or cytokine-specific blocking antibodies, rather than direct infusion of cytokines.

AB - The mechanisms of action of intravenous immunoglobulin (IVIg) in autoimmune diseases include modulation of cytokine levels. levels. examined therefore whether direct infusion of abnormally high levels of 13 different cytokines or cytokine-inhibitors within 5 different IVIg preparations have any role in modulation of their levels. None of the measured cytokines in any of the IVIg preparations tested were above the normal levels, and regarding some no traces could be detected. Hence, modulation of cytokine levels following IVIg therapy involves other mechanisms such as interference with their secretion or cytokine-specific blocking antibodies, rather than direct infusion of cytokines.

KW - Autoantibody

KW - Autoimmunity

KW - Cytokine

KW - Interleukin

KW - Intravenous immunoglobulin

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DO - 10.3233/hab-2001-10201

M3 - Article

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VL - 10

SP - 51

EP - 53

JO - Human Antibodies

JF - Human Antibodies

IS - 2

ER -

Cytokine levels in various intravenous immunoglobulin (IVIg) preparations

Abstract

Keywords

ASJC Scopus subject areas

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