Cytokines in amniotic fluid do not predict neonatal respiratory distress syndrome

F. Ghezzi, R. Romero, R. Gomez, M. Mazor, Tolosa B.H. Yoon

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: A recent study reported that the frequencv and severiu of respiratury distress symlrome (RDS) in prêterai birth was related to .imnioiir fluid (AF) concentration oi the inllaminalorv cytokine tumor necrosis hictor-α (TNF-α) (Am J Ohstet Gvnecoi 1996:174 [1]:471). This observation has considerable implications because it suggests that factors unrelated to gestational age may determine the occurrence of RDS. This study was designed to determine whether concentrations of pro-inflammatory cvtokines and chemokines. TNF-α, interleukin-6 (IL-6), inlerletikin-8 (1L-S), macrophage inflammatory protein (MIP)-1α and monoryte chemotactic prolein (MCP)-1 are independent predictors of RDS in a population ai risk for complication1, associated with prematuriu. STUDY DESIGN: Patients with preterm labor (n = 99) and PROM (n = 64) admitted between 24-34 completed weeks underwent amniocentesis for microbiologie studies of the amniotic cavity. Fluid was cultured for aerobic/ anaerobic bacteria and Mycoplasmas. Concentrations ot'AF cvtokines (IL-6 and TNF-α) and chemokines (IL-8 MIP-1α and MCP-1) were assessed by immunoassav. Statistical analysis was performed using non-parametric test, cnnungency tables and sunival analysis. RESULTS: The frequencv ol RDS was 55.8% (91/163). Univariate anahsis indicated that AF IL-α, TXF-α. MIP-1α and MCP-1 concentrations were significantly associated with the occurrence of RDS (p ≤ 0.05). However. contran to what has been previously reported by other investigatois, logistic- regression demonstrated that such relationship did not remain significant after adjusting for gestational age at delivery and/or birtlrvveighi (p > O.Ofi for all cvtokines). CONCLUSION: The risk of RDS does not increase as a function ol amniotic fluid concentrations oi chemokines or pro-inflammatory cvtokines in AF.

Original languageEnglish
Pages (from-to)S47
JournalActa Diabetologica Latina
Issue number1 PART II
StatePublished - 1 Dec 1997
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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