Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treatment of gastric cancer with peritoneal carcinomatosis

Lynne M. Ellison, Yangao Man, Alexander Stojadinovic, Hongwu Xin, Itzhak Avital

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Although gastric cancer with peritoneal carcinomatosis is associated with poor prognosis and is generally treated with palliative systemic therapy, recent studies have shown that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may prove to be an efficacious treatment option. In addition to reviewing the natural history of gastric cancer with peritoneal carcinomatosis, this mini-review examines literature on the efficacy of CRS and HIPEC as compared to chemotherapy and surgical options. Both randomized and non-randomized studies were summarized with the emphasis focused on overall survival. In summary, CRS and HIPEC are indeed a promising treatment option for gastric cancer with peritoneal carcinomatosis and large randomized clinical trials are warranted.

Original languageEnglish
Pages (from-to)86-92
Number of pages7
JournalChinese Journal of Cancer Research
Volume29
Issue number1
DOIs
StatePublished - 1 Feb 2017
Externally publishedYes

Keywords

  • Cytoreductive surgery
  • Hyperthermic intraperitoneal chemotherapy
  • Peritoneal carcinomatosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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