Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treatment of gastric cancer with peritoneal carcinomatosis

Lynne M. Ellison; Yangao Man; Alexander Stojadinovic; Hongwu Xin; Itzhak Avital

doi:10.21147/j.issn.1000-9604.2017.01.10

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treatment of gastric cancer with peritoneal carcinomatosis

Lynne M. Ellison, Yangao Man, Alexander Stojadinovic, Hongwu Xin, Itzhak Avital

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Although gastric cancer with peritoneal carcinomatosis is associated with poor prognosis and is generally treated with palliative systemic therapy, recent studies have shown that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may prove to be an efficacious treatment option. In addition to reviewing the natural history of gastric cancer with peritoneal carcinomatosis, this mini-review examines literature on the efficacy of CRS and HIPEC as compared to chemotherapy and surgical options. Both randomized and non-randomized studies were summarized with the emphasis focused on overall survival. In summary, CRS and HIPEC are indeed a promising treatment option for gastric cancer with peritoneal carcinomatosis and large randomized clinical trials are warranted.

Original language	English
Pages (from-to)	86-92
Number of pages	7
Journal	Chinese Journal of Cancer Research
Volume	29
Issue number	1
DOIs	https://doi.org/10.21147/j.issn.1000-9604.2017.01.10
State	Published - 1 Feb 2017
Externally published	Yes

Keywords

Cytoreductive surgery
Hyperthermic intraperitoneal chemotherapy
Peritoneal carcinomatosis

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21147/j.issn.1000-9604.2017.01.10

Cite this

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title = "Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treatment of gastric cancer with peritoneal carcinomatosis",

abstract = "Although gastric cancer with peritoneal carcinomatosis is associated with poor prognosis and is generally treated with palliative systemic therapy, recent studies have shown that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may prove to be an efficacious treatment option. In addition to reviewing the natural history of gastric cancer with peritoneal carcinomatosis, this mini-review examines literature on the efficacy of CRS and HIPEC as compared to chemotherapy and surgical options. Both randomized and non-randomized studies were summarized with the emphasis focused on overall survival. In summary, CRS and HIPEC are indeed a promising treatment option for gastric cancer with peritoneal carcinomatosis and large randomized clinical trials are warranted.",

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author = "Ellison, {Lynne M.} and Yangao Man and Alexander Stojadinovic and Hongwu Xin and Itzhak Avital",

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language = "English",

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TY - JOUR

T1 - Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treatment of gastric cancer with peritoneal carcinomatosis

AU - Ellison, Lynne M.

AU - Man, Yangao

AU - Stojadinovic, Alexander

AU - Xin, Hongwu

AU - Avital, Itzhak

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Although gastric cancer with peritoneal carcinomatosis is associated with poor prognosis and is generally treated with palliative systemic therapy, recent studies have shown that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may prove to be an efficacious treatment option. In addition to reviewing the natural history of gastric cancer with peritoneal carcinomatosis, this mini-review examines literature on the efficacy of CRS and HIPEC as compared to chemotherapy and surgical options. Both randomized and non-randomized studies were summarized with the emphasis focused on overall survival. In summary, CRS and HIPEC are indeed a promising treatment option for gastric cancer with peritoneal carcinomatosis and large randomized clinical trials are warranted.

AB - Although gastric cancer with peritoneal carcinomatosis is associated with poor prognosis and is generally treated with palliative systemic therapy, recent studies have shown that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may prove to be an efficacious treatment option. In addition to reviewing the natural history of gastric cancer with peritoneal carcinomatosis, this mini-review examines literature on the efficacy of CRS and HIPEC as compared to chemotherapy and surgical options. Both randomized and non-randomized studies were summarized with the emphasis focused on overall survival. In summary, CRS and HIPEC are indeed a promising treatment option for gastric cancer with peritoneal carcinomatosis and large randomized clinical trials are warranted.

KW - Cytoreductive surgery

KW - Hyperthermic intraperitoneal chemotherapy

KW - Peritoneal carcinomatosis

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DO - 10.21147/j.issn.1000-9604.2017.01.10

M3 - Review article

AN - SCOPUS:85028079114

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Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treatment of gastric cancer with peritoneal carcinomatosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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